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  1. Article

    Open Access

    Effects of exercise training on cardiac output in subjects with heart failure with preserved ejection fraction (HFpEF) — a protocol for a systematic review and meta-analysis

    Patients with heart failure with preserved ejection fraction (HFpEF) commonly experience exercise intolerance, resulting in reduced cardiorespiratory fitness. This is characterised by a decreased maximal oxyge...

    Raphael Schoch, Benedikt Gasser, Philippe Beck in Systematic Reviews (2024)

  2. Article

    Open Access

    Multidimensional versus unidimensional pain scales for the assessment of analgesic requirement in the emergency department: a systematic review

    Pain is a multidimensional experience, potentially rendering unidimensional pain scales inappropriate for assessment. Prior research highlighted their inadequacy as reliable indicators of analgesic requirement...

    Elena Crisman, Christian Appenzeller-Herzog in Internal and Emergency Medicine (2024)

  3. Article

    Open Access

    Predicting neurological outcome in adult patients with cardiac arrest: systematic review and meta-analysis of prediction model performance

    This work aims to assess the performance of two post-arrest (out-of-hospital cardiac arrest, OHCA, and cardiac arrest hospital prognosis, CAHP) and one pre-arrest (good outcome following attempted resuscitatio...

    Simon A. Amacher, René Blatter, Matthias Briel in Critical Care (2022)

  4. Article

    Open Access

    The Metabolic Signature of Cardiorespiratory Fitness: A Systematic Review

    Cardiorespiratory fitness (CRF) is a potent health marker, the improvement of which is associated with a reduced incidence of non-communicable diseases and all-cause mortality. Identifying metabolic signatures...

    Justin Carrard, Chiara Guerini, Christian Appenzeller-Herzog in Sports Medicine (2022)

  5. Article

    Open Access

    Prognostic factors for the occurrence of post-operative shoulder stiffness after arthroscopic rotator cuff repair: a systematic review

    Post-operative shoulder stiffness (POSS) is one of the most frequent complications after arthroscopic rotator cuff repair (ARCR). Factors specifying clinical prediction models for the occurrence of POSS should...

    Thomas Stojanov, Linda Modler, Andreas M. Müller in BMC Musculoskeletal Disorders (2022)

  6. Article

    Open Access

    Methodological approaches for conducting follow-up research with clinical trial participants: a sco** review and expert interviews

    Evidence-based establishment and implementation of best principles, laws and ordinances that regulate clinical research depend on the consultation and involvement of trial participants. Yet, guidance on method...

    Aita Signorell, Jasmina Saric, Christian Appenzeller-Herzog, Hannah Ewald in Trials (2021)

  7. Article

    Open Access

    Antibiotic prophylaxis in transurethral resection of bladder tumours: study protocol for a systematic review and meta-analysis

    The necessity of antibiotic prophylaxis for postoperative urinary tract infections (UTIs) after transurethral resection of bladder tumours is controversial. This potentially leads to the overuse of antibiotic ...

    Kathrin Bausch, Soheila Aghlmandi, Sarah Ursula Sutter in Systematic Reviews (2020)

  8. Article

    Open Access

    Ca2+ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione

    The lumen of the endoplasmic reticulum (ER) acts as a cellular Ca2+ store and a site for oxidative protein folding, which is controlled by the reduced glutathione (GSH) and glutathione-disulfide (GSSG) redox pair...

    Beáta Lizák, Julia Birk, Melinda Zana, Gergely Kosztyi, Denise V. Kratschmar in BMC Biology (2020)

  9. No Access

    Article

    Impact of sedentary behavior on large artery structure and function in children and adolescents: a systematic review

    Sedentary behavior contributes to increased atherosclerotic risk in adults. Whether or not this can be extended to pediatric populations is unclear. This systematic review assessed associations of sedentary be...

    Karsten Königstein, Christopher Klenk in European Journal of Pediatrics (2020)