57 Result(s)
within
Javier Herrero
English
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Article
Open AccessAuthor Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx
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Open AccessThe evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer...
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Open AccessAberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone
Oncohistones represent compelling evidence for a causative role of epigenetic perturbations in cancer. Giant cell tumours of bone (GCTs) are characterised by a mutated histone H3.3 as the sole genetic driver p...
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Open AccessAuthor Correction: Comparative and demographic analysis of orang-utan genomes
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Snow Dynamics, Hydrology, and Erosion
is the area in Europe and its singular geographical location, together with its high altitudes, result in strong gradients of the and hydrology, and . This chapter aims at providing insights into the maj...
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Open AccessThe significance of monitoring high mountain environments to detect heavy precipitation hotspots: a case study in Gredos, Central Spain
In 2015, a new automatic weather station (AWS) was installed in a high elevation site in Gredos mountains (Central System, Spain). Since then, a surprisingly high number of heavy precipitation events have been...
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Article
Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia
Comparison of intratumor genetic heterogeneity in cancer at diagnosis and relapse suggests that chemotherapy induces bottleneck selection of subclonal genotypes. However, evolutionary events subsequent to chem...
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Co-design of a TV-based home support for early stage of dementia
This article describes the work done to create an innovative system to support people with Mild Cognitive Impairment or Mild Dementia. The basic idea of the system is to exploit an extremely simple and familia...
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Open AccessEscape from nonsense-mediated decay associates with anti-tumor immunogenicity
Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some...
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Publisher Correction: A clonal expression biomarker associates with lung cancer mortality
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessConstruction of a high density linkage map in Oil Palm using SPET markers
A high-density genetic linkage map from a controlled cross of two oil palm (Elaeis guineensis) genotypes was constructed based on Single Primer Enrichment Technology (SPET) markers. A 5K panel of hybridization pr...
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The T cell differentiation landscape is shaped by tumour mutations in lung cancer
Tumour mutational burden (TMB) predicts immunotherapy outcome in non-small cell lung cancer (NSCLC), consistent with immune recognition of tumour neoantigens. However, persistent antigen exposure is detrimenta...
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Author Correction: G-tract RNA removes Polycomb repressive complex 2 from genes
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessThe Personal Genome Project-UK, an open access resource of human multi-omics data
Integrative analysis of multi-omics data is a powerful approach for gaining functional insights into biological and medical processes. Conducting these multifaceted analyses on human samples is often complicat...
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Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer
Somatic mutations together with immunoediting drive extensive heterogeneity within non-small-cell lung cancer (NSCLC). Herein we examine heterogeneity of the T cell antigen receptor (TCR) repertoire. The numbe...
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G-tract RNA removes Polycomb repressive complex 2 from genes
Polycomb repressive complex 2 (PRC2) maintains repression of cell-type-specific genes but also associates with genes ectopically in cancer. While it is currently unknown how PRC2 is removed from genes, such kn...
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A clonal expression biomarker associates with lung cancer mortality
An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage1. Transcriptomic intr...
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Open AccessEnhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute to cell-type specific genome structure is poorly understood. Here, we explore quantitative aspects of topolog...
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Neoantigen-directed immune escape in lung cancer evolution
The interplay between an evolving cancer and a dynamic immune microenvironment remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell lung cancers using RNA sequencing and h...
