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  1. No Access

    Article

    Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia

    Comparison of intratumor genetic heterogeneity in cancer at diagnosis and relapse suggests that chemotherapy induces bottleneck selection of subclonal genotypes. However, evolutionary events subsequent to chem...

    Virginia A. Turati, José Afonso Guerra-Assunção, Nicola E. Potter… in Nature Cancer (2021)

  2. Article

    Open Access

    The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia

    Single-cell genetics were used to interrogate clonal complexity and the sequence of mutational events in STIL-TAL1+ T-ALL. Single-cell multicolour FISH was used to demonstrate that the earliest detectable leukaem...

    Caroline L Furness, Marcela B Mansur, Victoria J Weston, Luca Ermini… in Leukemia (2018)

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  3. No Access

    Article

    Persistence of leukaemic ancestors

    The early development of acute leukaemias is assumed for the most part to be clinically silent and transient. But it now seems that ancestral precancerous cells are identifiable and persistent. See Article ...

    Nicola E. Potter, Mel Greaves in Nature (2014)

  4. No Access

    Article

    RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

    Peter Campbell, Mel Greaves and colleagues use exome and whole-genome sequencing to characterize somatic mutations in childhood acute lymphoblastic leukemias with the ETV6-RUNX1 fusion gene. They find that RAG-me...

    Elli Papaemmanuil, Inmaculada Rapado, Yilong Li, Nicola E Potter… in Nature Genetics (2014)