5 Result(s)
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Christopher Barrington
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Article
Open AccessDetection of chromosomal aneuploidy in ancient genomes
Ancient DNA is a valuable tool for investigating genetic and evolutionary history that can also provide detailed profiles of the lives of ancient individuals. In this study, we develop a generalised computatio...
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Article
Open AccessSmad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways
The transcriptional effector SMAD4 is a core component of the TGF-β family signaling pathways. However, its role in vertebrate embryo development remains unresolved. To address this, we deleted Smad4 in zebraf...
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Article
Open AccessFission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage
Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range chrom...
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Article
Open AccessEnhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute to cell-type specific genome structure is poorly understood. Here, we explore quantitative aspects of topolog...
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Article
Open AccessCohesin biology meets the loop extrusion model
Extensive research has revealed that cohesin acts as a topological device, trap** chromosomal DNA within a large tripartite ring. In so doing, cohesin contributes to the formation of compact and organized ge...
