-
Article
Open AccessAuthor Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx
-
Article
Open AccessPD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy
Checkpoint inhibition (CPI), particularly that targeting the inhibitory coreceptor programmed cell death protein 1 (PD-1), has transformed oncology. Although CPI can derepress cancer (neo)antigen-specific αβ T...
-
Article
Evolutionary characterization of lung adenocarcinoma morphology in TRACERx
Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform and micropapillary tumors. How morpho...
-
Article
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy1. The study of large patient cohorts incorporating longitudinal plasma sampling and ...
-
Article
Open AccessThe evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer...
-
Article
Open AccessRAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma
Activating mutations in KRAS occur in 32% of lung adenocarcinomas (LUAD). Despite leading to aggressive disease and resistance to therapy in preclinical studies, the KRAS mutation does not predict patient outcome...
-
Article
Open AccessA local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show ...
-
Article
Pervasive chromosomal instability and karyotype order in tumour evolution
Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes1,2. The resulting diversity in somatic copy number alterations (SCNAs) may provide the variation necessary ...
-
Article
Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Scalable and robust SARS-CoV-2 testing in an academic center
-
Article
Publisher Correction: A clonal expression biomarker associates with lung cancer mortality
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
The T cell differentiation landscape is shaped by tumour mutations in lung cancer
Tumour mutational burden (TMB) predicts immunotherapy outcome in non-small cell lung cancer (NSCLC), consistent with immune recognition of tumour neoantigens. However, persistent antigen exposure is detrimenta...
-
Article
A clonal expression biomarker associates with lung cancer mortality
An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage1. Transcriptomic intr...
-
Article
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse
Approximately 50% of patients with early-stage non-small-cell lung cancer (NSCLC) who undergo surgery with curative intent will relapse within 5 years1,2. Detection of circulating tumor cells (CTCs) at the time o...
