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Open AccessRapid reconstitution of ubiquitinated nucleosome using a non-denatured histone octamer ubiquitylation approach
Histone ubiquitination modification is emerging as a critical epigenetic mechanism involved in a range of biological processes. In vitro reconstitution of ubiquitinated nucleosomes is pivotal for elucidating t...
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Author Correction: G-tract RNA removes Polycomb repressive complex 2 from genes
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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G-tract RNA removes Polycomb repressive complex 2 from genes
Polycomb repressive complex 2 (PRC2) maintains repression of cell-type-specific genes but also associates with genes ectopically in cancer. While it is currently unknown how PRC2 is removed from genes, such kn...
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Open AccessStructural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense mutation in the substrate of PRC2, histone H3K27M, ...
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Histone Recognition by WD40 Proteins
Chromatin-associated complexes often contain proteins with WD40 repeat domains that mediate interactions with the histone proteins. However, histone recognition by this family is not achieved through a single ...
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Role of the polycomb protein EED in the propagation of repressive histone marks
Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to tr...
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Regulation of p53 activity through lysine methylation
p53 is a tumour suppressor that regulates the cellular response to genotoxic stresses. p53 is a short-lived protein and its activity is regulated mostly by stabilization via different post-translational modifi...
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Structure of the key toxin in gas gangrene
Clostridium perfringens α-toxin is the key virulence determinant in gas gangrene and has also been implicated in the pathogenesis of sudden death syndrome in young animals. The toxin is a 370-residue, zinc metall...
