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Article
Open AccessAberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone
Oncohistones represent compelling evidence for a causative role of epigenetic perturbations in cancer. Giant cell tumours of bone (GCTs) are characterised by a mutated histone H3.3 as the sole genetic driver p...
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Article
Open AccessRepo-Man/PP1 regulates heterochromatin formation in interphase
Repo-Man is a protein phosphatase 1 (PP1) targeting subunit that regulates mitotic progression and chromatin remodelling. After mitosis, Repo-Man/PP1 remains associated with chromatin but its function in inter...