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  1. Article

    Open Access

    Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis

    The IL23R region on chromosome 1 exhibits complex associations with ankylosing spondylitis (AS). We used publicly available epigenomic information and historical genetic association data to identify a putative re...

    A R Roberts, M Vecellio, A Cortes, J C Knight, C J Cohen… in Genes & Immunity (2017)

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  2. Article

    Open Access

    Erratum: A functional AT/G polymorphism in the 5′-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14

    Correction to: Genes and Immunity (2015) 16, 488–494; doi:10.1038/gene.2015.36; published online 17 September 2015 Updated online 12 May 2016: This article was originally published under a CC BY-NC-SA 4.0 lice...

    R J Holt, C Vandiedonck, S A Willis-Owen, J C Knight, W O Cookson… in Genes & Immunity (2017)

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  3. Article

    Open Access

    A functional AT/G polymorphism in the 5′-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14

    The immunoglobulin E (IgE)-associated locus on human chromosome 13q14 influencing asthma-related traits contains the genes PHF11 and SETDB2. SETDB2 is located in the same linkage disequilibrium region as PHF11 an...

    R J Holt, C Vandiedonck, S A Willis-Owen, J C Knight, W O Cookson… in Genes & Immunity (2015)

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  4. Article

    Open Access

    Transcriptional repression and DNA loo** associated with a novel regulatory element in the final exon of the lymphotoxin-β gene

    Transcriptional regulation has a critical role in the coordinate and context-specific expression of a cluster of genes encoding members of the tumour necrosis factor (TNF) superfamily found at chromosome 6p21,...

    K Wicks, J C Knight in Genes & Immunity (2011)

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  5. No Access

    Article

    Regulation of major histocompatibility complex class II gene expression, genetic variation and disease

    Major histocompatibility complex (MHC) class II molecules are central to adaptive immune responses and maintenance of self-tolerance. Since the early 1970s, the MHC class II region at chromosome 6p21 has been ...

    L Handunnetthi, S V Ramagopalan, G C Ebers, J C Knight in Genes & Immunity (2010)

  6. No Access

    Article

    Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility

    Interleukin-8 (IL-8) has been implicated in the pathogenesis of RSV-induced bronchiolitis. Previously, we have described an association between bronchiolitis disease severity and a specific IL-8 haplotype comp...

    D Hacking, J C Knight, K Rockett, H Brown, J Frampton, D P Kwiatkowski… in Genes & Immunity (2004)

  7. No Access

    Article

    Two Cases of Pulmonary Complications Associated with a Recently Recognised Salmonella enteritidis Phage Type, 21b, Affecting Immunocompetent Adults

    J. C. Knight, M. Knight, M. J. Smith in European Journal of Clinical Microbiology … (2000)