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Article
Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability
HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake. To study genetically determined differences in HFE expression we examined individual HFE l...
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Article
The Macrophage: A Cellular Factory at the Interphase Between Iron and Immunity for the Control of Infections
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Article
Pyopneumothorax due to Streptococcus milleri
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Article
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
Hereditary hemochromatosis and transfusional iron overload are frequent clinical conditions associated with progressive iron accumulation in parenchymal tissues, leading to eventual organ failure. We have disc...
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Article
Short term protective effects of iron in a murine model of ischemia/reperfusion
The role of iron in the pathogenesis of cardio-vascular disorders is still controversial. We studied the effects of iron perturbations on myocardial injury upon temporary ischemia/reperfusion. C57BL/6J male mi...
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Article
Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression
Hepcidin, a small cationic liver derived peptide, is a master regulator of body iron homeostasis. Cytokines and iron availability have so far been identified as regulators of hepcidin expression. Herein, we in...
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Article
Open AccessIL-17 as an important effector cytokine in a mouse model for S.typhimurium sepsis
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Article
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
Macrophages are abundant in atherosclerotic plaques and are a pivotal cell type in plaque formation and progression. But how do they get there? Filip Swirski and his colleagues show that, contrary to most prev...
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Article
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Damaged erythrocytes accumulate in various pathological conditions, such as hemolytic anemia, anemia of inflammation, and sickle cell disease. In mice challenged with damaged erythorcytes, a monocyte subset mi...
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Article
Open AccessIron deficiency or anemia of inflammation?
Iron deficiency and immune activation are the two most frequent causes of anemia, both of which are based on disturbances of iron homeostasis. Iron deficiency anemia results from a reduction of the body’s iron...
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Article
Open Access“Pum** iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels
Macrophages reside in virtually every organ. First arising during embryogenesis, macrophages replenish themselves in the adult through a combination of self-renewal and influx of bone marrow-derived monocytes....
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Article
Open AccessCibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis
Two distinct forms of the erythropoietin receptor (EPOR) mediate the cellular responses to erythropoietin (EPO) in different tissues. EPOR homodimers signal to promote the maturation of erythroid progenitor ce...
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Article
Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signalling
Transferrin receptor 2 (Tfr2) is mainly expressed in the liver and controls iron homeostasis. Here, we identify Tfr2 as a regulator of bone homeostasis that inhibits bone formation. Mice lacking Tfr2 display i...
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Author Correction: Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling
In the version of this article initially published, affiliation 14 was incorrect, and Deutsche Forschungsgemeinschaft grants SFB1036 and SFB1118 were missing from the Acknowledgements. The errors have been cor...
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Article
Open AccessLinkage of alterations in systemic iron homeostasis to patients’ outcome in sepsis: a prospective study
Sepsis, a dysregulated host response following infection, is associated with massive immune activation and high mortality rates. There is still a need to define further risk factors and laboratory parameters p...
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Article
Open AccessRisk assessment in precapillary pulmonary hypertension: a comparative analysis
Risk stratification is essential to assess mortality risk and guide treatment in patients with precapillary pulmonary hypertension (PH). We herein compared the accuracy of different currently used PH risk stra...
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Article
Open AccessOvercoming limitations in the availability of swabs systems used for SARS-CoV-2 laboratory diagnostics
The diagnosis of COVID-19 relies on the direct detection of SARS-CoV-2 RNA in respiratory specimens by RT-PCR. The pandemic spread of the disease caused an imbalance between demand and supply of materials and ...
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Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values
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Open AccessQuantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19
The CovILD study is a prospective, multicenter, observational cohort study to systematically follow up patients after coronavirus disease-2019 (COVID-19). We extensively evaluated 145 COVID-19 patients at 3 fo...
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Article
Open AccessPulmonary recovery from COVID-19 in patients with metabolic diseases: a longitudinal prospective cohort study
The severity of coronavirus disease 2019 (COVID-19) is related to the presence of comorbidities including metabolic diseases. We herein present data from the longitudinal prospective CovILD trial, and investig...
