44 Result(s)
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Martina U Muckenthaler
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Open AccessDynamic YAP expression in the non-parenchymal liver cell compartment controls heterologous cell communication
The Hippo pathway and its transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are targets for cancer therapy. It is important to determine if the...
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Author Correction: Consensus Statement on the definition and classification of metabolic hyperferritinaemia
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Alterations of iron homeostasis as a potential druggable driver of long COVID
Drivers of persistent symptoms after acute COVID-19 remain largely unknown. Alterations in immune function, iron homeostasis and dysregulated erythropoiesis are described as treatable correlates of post-acute ...
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Consensus Statement on the definition and classification of metabolic hyperferritinaemia
Hyperferritinaemia is a common laboratory finding that is often associated with metabolic dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron metabolism that facilitate iron ...
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Open AccessT cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles
Glioblastoma, the most common and aggressive primary brain tumor type, is considered an immunologically “cold” tumor with sparse infiltration by adaptive immune cells. Immunosuppressive tumor-associated myeloi...
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Open AccessChemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group
Characterization of clinical phenotypes in context with tumor and host genomic information can aid in the development of more effective and less toxic risk-adapted and targeted treatment strategies. To analyze...
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Open AccessPediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution
The mechanisms underlying T-ALL relapse remain essentially unknown. Multilevel-omics in 38 matched pairs of initial and relapsed T-ALL revealed 18 (47%) type-1 (defined by being derived from the major ancestra...
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Spurenelemente
Viele Elemente kommen in Geweben in so geringen Konzentrationen vor (1 × 10–6 bis 10–12 g/g Feuchtgewicht des Organs), dass es mit den früher verfügbaren analytischen Methoden unmöglich war, ihre Konzentration...
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Open AccessPrognostic impact of hypochromic erythrocytes in patients with pulmonary arterial hypertension
Iron deficiency affects up to 50% of patients with pulmonary arterial hypertension (PAH) but iron markers such as ferritin and serum iron are confounded by several non-disease related factors like acute inflam...
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Open AccessIron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these fin...
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Author Correction: Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling
In the version of this article initially published, affiliation 14 was incorrect, and Deutsche Forschungsgemeinschaft grants SFB1036 and SFB1118 were missing from the Acknowledgements. The errors have been cor...
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Air–blood barrier thickening and alterations of alveolar epithelial type 2 cells in mouse lungs with disrupted hepcidin/ferroportin regulatory system
Iron accumulates in the lungs of patients with common respiratory diseases or transfusion-dependent beta-thalassemia. Based on our previous work, we hypothesized that systemic iron overload affects the alveola...
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Open AccessmiR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma
Transferrin receptor 1 (TFR1) is a transmembrane glycoprotein that allows for transferrin-bound iron uptake in mammalian cells. It is overexpressed in various cancers to satisfy the high iron demand of fast pr...
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Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signalling
Transferrin receptor 2 (Tfr2) is mainly expressed in the liver and controls iron homeostasis. Here, we identify Tfr2 as a regulator of bone homeostasis that inhibits bone formation. Mice lacking Tfr2 display i...
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Open AccessDietary stearic acid regulates mitochondria in vivo in humans
Since modern foods are unnaturally enriched in single metabolites, it is important to understand which metabolites are sensed by the human body and which are not. We previously showed that the fatty acid stear...
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Open AccessMAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB
Deletions of 6q15–16.1 are recurrently found in pediatric T-cell acute lymphoblastic leukemia (T-ALL). This chromosomal region includes the mitogen-activated protein kinase kinase kinase 7 (MAP3K7) gene which has...
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Open AccessThe hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
Macrophages release iron into the bloodstream via a membrane-bound iron export protein, ferroportin (FPN). The hepatic iron-regulatory hormone hepcidin controls FPN internalization and degradation in response ...
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Uncoupled iron homeostasis in type 2 diabetes mellitus
Diabetes mellitus is frequently associated with iron overload conditions, such as primary and secondary hemochromatosis. Conversely, patients affected by type 2 diabetes mellitus (T2DM) show elevated ferritin ...
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Open AccessHepcidin is regulated by promoter-associated histone acetylation and HDAC3
Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis. Her...
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Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin
Expression of the hepatic peptide hormone hepcidin responds to iron levels via BMP/SMAD signaling, to inflammatory cues via JAK/STAT signaling, to the nutrient-sensing mTOR pathway, as well as to proliferative...
