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Macrophage niche availability enables local monocyte proliferation in peripheral tissues
Mononuclear phagocyte proliferation is thought to be limited to myeloid progenitor cells and mature macrophages. However, availability within an interstitial macrophage niche permits the proliferation of monoc...
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Open AccessDj1 deficiency protects against atherosclerosis with anti-inflammatory response in macrophages
Inflammation is a key contributor to atherosclerosis with macrophages playing a pivotal role through the induction of oxidative stress and cytokine/chemokine secretion. DJ1, an anti-oxidant protein, has shown ...
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Open AccessInhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering
Statins induce plaque regression characterized by reduced macrophage content in humans, but the underlying mechanisms remain speculative. Studying the translational APOE*3-Leiden.CETP mouse model with a humani...
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Article
Open AccessA durable murine model of spleen transplantation with arterial and venous anastomoses
The spleen is a large lymphoid organ located in the abdomen that filters blood and regulates the immune system. The extent of mobilization of splenic immune cells to peripheral tissues in health and disease, h...
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Publisher Correction: Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction
In the version of this article initially published, the equal contribution of the third author was omitted. The footnote links for that author should be “Sara Nejat1,11” and the correct statement is as follows: “
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Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction
Macrophages promote both injury and repair after myocardial infarction, but discriminating functions within mixed populations remains challenging. Here we used fate map**, parabiosis and single-cell transcri...
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Open AccessMacrophage JAK2 deficiency protects against high-fat diet-induced inflammation
During obesity, macrophages can infiltrate metabolic tissues, and contribute to chronic low-grade inflammation, and mediate insulin resistance and diabetes. Recent studies have elucidated the metabolic role of...
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Erratum: CCL19-CCR7–dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima
Nat. Immunol. 17, 1263–1272 (2016); published online 26 September 2016; corrected after print 20 March 2017 In the version of this article initially published, the label along the horizontal axis of the graph ...
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CCL19-CCR7–dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima
Cybulsky and colleagues show that myeloid cells in the arterial intima undergo reverse transendothelial migration into the arterial circulation that is dependent on the chemokine CCL19 and its receptor CCR7.
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Open AccessAtheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression
Macrophages in the arterial intima sustain chronic inflammation during atherogenesis. Under hypercholesterolemic conditions murine Ly6Chigh monocytes surge in the blood and spleen, infiltrate nascent atherosclero...
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Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth
Macrophages densely populate the arterial wall, yet their origin and homeostasis are poorly understood. Robbins and colleagues show that arterial macrophages arise from CX3CR1+ embryonic precursors and adult bone...
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Article
From proliferation to proliferation: monocyte lineage comes full circle
Monocytes are mononuclear circulating phagocytes that originate in the bone marrow and give rise to macrophages in peripheral tissue. For decades, our understanding of monocyte lineage was bound to a stepwise ...
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Local proliferation dominates lesional macrophage accumulation in atherosclerosis
Macrophages are abundant in atherosclerotic plaques and are a pivotal cell type in plaque formation and progression. But how do they get there? Filip Swirski and his colleagues show that, contrary to most prev...
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Myocardial infarction accelerates atherosclerosis
During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaques in the arterial wall and cause their rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary s...
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The multiple roles of monocyte subsets in steady state and inflammation
Monocytes participate importantly in immunity. Produced in the bone marrow and released into the blood, they circulate in blood or reside in a spleen reservoir before entering tissue and giving rise to macroph...
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Article
Macrophage elastase kills bacteria within murine macrophages
Normal physiologic roles for many of the matrix metalloproteinases (MMPs), an extensive family of zinc-dependent endopeptidases, remain poorly understood. Matrix metalloproteinase-12 (MMP-12, also known as mac...
