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Article
Open AccessReview: The Role of Dual-Energy Computed Tomography in Detecting Monosodium Urate Deposits in Vascular Tissues
To highlight novel findings in the detection of monosodium urate deposits in vessels using dual energy computed tomography, and to discuss the potential clinical implications for gout and hyperuricemia patients.
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Article
Open AccessLaboratory parameters related to disease severity and physical performance after reconvalescence of acute COVID-19 infection
Research into the molecular basis of disease trajectory and Long-COVID is important to get insights toward underlying pathophysiological processes. The objective of this study was to investigate inflammation-m...
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Article
Open AccessDistinct smell and taste disorder phenotype of post-acute COVID-19 sequelae
Olfactory dysfunction (OD) commonly accompanies coronavirus disease 2019 (COVID-19). We investigated the kinetics of OD resolution following SARS-CoV-2 infection (wild-type and alpha variant) and its impact on...
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Article
Open Access1.5-T MR relaxometry in quantifying splenic and pancreatic iron: retrospective comparison of a commercial 3D-Dixon sequence and an established 2D multi-gradient echo sequence
To compare the quantitative measurement of splenic and pancreatic iron content using a commercial 3D-Dixon sequence (qDixon) versus an established fat-saturated R2* relaxometry method (ME-GRE).
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Article
Open AccessThe combination of supervised and unsupervised learning based risk stratification and phenoty** in pulmonary arterial hypertension—a long-term retrospective multicenter trial
Accurate risk stratification in pulmonary arterial hypertension (PAH), a devastating cardiopulmonary disease, is essential to guide successful therapy. Machine learning may improve risk management and harness ...
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Article
Open AccessConsensus Statement der Österreichischen Gesellschaften für Rheumatologie und Rehabilitation, Pneumologie, Infektiologie, Dermatologie und Gastroenterologie zum Umgang mit latenter Tuberkulose bei Therapien mit biologischen oder „targeted synthetic“ DMARDs („disease modifying antirheumatic drugs“)
In diesem österreichweiten Consensus Statement sind die Empfehlungen zum Umgang mit latenter Tuberkulose bei Therapie mit biologischen und „targeted synthetic“ DMARDs zusammengefasst. Die wesentlichen Fragen b...
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Article
Open AccessPulmonary recovery from COVID-19 in patients with metabolic diseases: a longitudinal prospective cohort study
The severity of coronavirus disease 2019 (COVID-19) is related to the presence of comorbidities including metabolic diseases. We herein present data from the longitudinal prospective CovILD trial, and investig...
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Article
Macrophage vesicles starve bacteria of iron
Iron is a growth factor for many microbes, and its availability is critical for the course of infections. A new study uncovers a mechanism by which extracellular vesicles released by macrophages withdraw iron ...
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Open AccessNational consensus statement by the Austrian Societies for Rheumatology, Pulmonology, Infectiology, Dermatology and Gastroenterology regarding the management of latent tuberculosis and the associated utilization of biologic and targeted synthetic disease modifying antirheumatic drugs (DMARDs)
This publication provides a thorough analysis of the most relevant topics concerning the management of latent tuberculosis when using biologic and targeted synthetic Disease Modifying Antirheumatic Drugs (DMAR...
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Article
Open AccessSarcoid-like lesions obfuscating the diagnosis of disseminated Mycobacterium genavense infection in a patient with IL-12Rβ1-associated immunodeficiency
Sarcoidosis is a systemic inflammatory disease that is characterized by non-caseating epithelioid-cell granulomas upon histology. However, similar histological findings may also be seen with certain infections...
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Article
Open AccessQuantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19
The CovILD study is a prospective, multicenter, observational cohort study to systematically follow up patients after coronavirus disease-2019 (COVID-19). We extensively evaluated 145 COVID-19 patients at 3 fo...
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Iron Deficiency and Anemia Associated with Infectious and Inflammatory Diseases
A balanced iron metabolism is of major importance for all living organisms. During infection and inflammation, iron homeostasis undergoes subtle alterations that are based on host defense mechanisms against in...
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Article
Rapid antigen testing and non-infectious shedding of SARS-Cov2
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Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values
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Open AccessOvercoming limitations in the availability of swabs systems used for SARS-CoV-2 laboratory diagnostics
The diagnosis of COVID-19 relies on the direct detection of SARS-CoV-2 RNA in respiratory specimens by RT-PCR. The pandemic spread of the disease caused an imbalance between demand and supply of materials and ...
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Article
Open AccessRisk assessment in precapillary pulmonary hypertension: a comparative analysis
Risk stratification is essential to assess mortality risk and guide treatment in patients with precapillary pulmonary hypertension (PH). We herein compared the accuracy of different currently used PH risk stra...
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Article
Open AccessPersisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study
Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmet...
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Open AccessLinkage of alterations in systemic iron homeostasis to patients’ outcome in sepsis: a prospective study
Sepsis, a dysregulated host response following infection, is associated with massive immune activation and high mortality rates. There is still a need to define further risk factors and laboratory parameters p...
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Article
Open AccessWill the COVID-19 pandemic slow down in the Northern hemisphere by the onset of summer? An epidemiological hypothesis
The COVID-19 pandemic has affected most countries of the world. As corona viruses are highly prevalent in the cold season, the question remains whether or not the pandemic will improve with increasing temperat...
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Article
Open AccessAnaemia, iron homeostasis and pulmonary hypertension: a review
Anaemia is a highly prevalent condition, which negatively impacts on patients’ cardiovascular performance and quality of life. Anaemia is mainly caused by disturbances of iron homeostasis. While absolute iron ...
