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Open AccessLaboratory parameters related to disease severity and physical performance after reconvalescence of acute COVID-19 infection
Research into the molecular basis of disease trajectory and Long-COVID is important to get insights toward underlying pathophysiological processes. The objective of this study was to investigate inflammation-m...
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Article
Open AccessDistinct smell and taste disorder phenotype of post-acute COVID-19 sequelae
Olfactory dysfunction (OD) commonly accompanies coronavirus disease 2019 (COVID-19). We investigated the kinetics of OD resolution following SARS-CoV-2 infection (wild-type and alpha variant) and its impact on...
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Article
Open AccessThe combination of supervised and unsupervised learning based risk stratification and phenoty** in pulmonary arterial hypertension—a long-term retrospective multicenter trial
Accurate risk stratification in pulmonary arterial hypertension (PAH), a devastating cardiopulmonary disease, is essential to guide successful therapy. Machine learning may improve risk management and harness ...
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Article
Open AccessPulmonary recovery from COVID-19 in patients with metabolic diseases: a longitudinal prospective cohort study
The severity of coronavirus disease 2019 (COVID-19) is related to the presence of comorbidities including metabolic diseases. We herein present data from the longitudinal prospective CovILD trial, and investig...
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Article
Open AccessFactors associated with impaired quality of life three months after being diagnosed with COVID-19
To assess patient characteristics associated with health-related quality of life (HR-QoL) and its mental and physical subcategories 3 months after diagnosis with COVID-19.
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Article
Open AccessQuantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19
The CovILD study is a prospective, multicenter, observational cohort study to systematically follow up patients after coronavirus disease-2019 (COVID-19). We extensively evaluated 145 COVID-19 patients at 3 fo...
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Open AccessOvercoming limitations in the availability of swabs systems used for SARS-CoV-2 laboratory diagnostics
The diagnosis of COVID-19 relies on the direct detection of SARS-CoV-2 RNA in respiratory specimens by RT-PCR. The pandemic spread of the disease caused an imbalance between demand and supply of materials and ...
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Article
Open AccessRisk assessment in precapillary pulmonary hypertension: a comparative analysis
Risk stratification is essential to assess mortality risk and guide treatment in patients with precapillary pulmonary hypertension (PH). We herein compared the accuracy of different currently used PH risk stra...
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Article
Open AccessPersisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study
Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmet...
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Open AccessAnaemia, iron homeostasis and pulmonary hypertension: a review
Anaemia is a highly prevalent condition, which negatively impacts on patients’ cardiovascular performance and quality of life. Anaemia is mainly caused by disturbances of iron homeostasis. While absolute iron ...
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Article
Open AccessCibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis
Two distinct forms of the erythropoietin receptor (EPOR) mediate the cellular responses to erythropoietin (EPO) in different tissues. EPOR homodimers signal to promote the maturation of erythroid progenitor ce...
