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Article
Open AccessIceCube – Neutrinos in Deep Ice
During the public Kaggle competition “IceCube – Neutrinos in Deep Ice”, thousands of reconstruction algorithms were created and submitted, aiming to estimate the direction of neutrino events recorded by the Ic...
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Article
Open AccessHow many dark neutrino sectors does cosmology allow?
We present the very first constraints on the number of Standard Model (SM) copies with an additional Dirac right-handed neutrino. From cosmology, we are able to pose strong limits on large regions of the param...
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Article
Open AccessCritical care management of acute intoxications, dynamics and changes over time: a cohort study
Acute intoxications and poisonings are a relevant cause for ICU admission of critically ill patients. This study aimed to determine the characteristics of intoxicated patients in a tertiary center medical ICU ...
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Article
Open AccessSoluble urokinase plasminogen activator receptor (suPAR) in bronchoalveolar fluid and blood in critically ill patients—a prospective cohort study
Soluble urokinase plasminogen activator receptor (suPAR) is a biologically active protein and increased levels are associated with worse outcomes in critically ill patients. suPAR in bronchoalveolar fluid (BAL...
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Article
Open AccessCOVID-19 associated Pulmonary Aspergillosis in Patients Admitted to the Intensive Care Unit: Impact of Antifungal Prophylaxis
Early after the beginning of the coronavirus disease 2019 (COVID-19)-pandemic, it was observed that critically ill patients in the intensive care unit (ICU) were susceptible to develo** secondary fungal infe...
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Article
Open AccessEffects of an online information tool on post-traumatic stress disorder in relatives of intensive care unit patients: a multicenter double-blind, randomized, placebo-controlled trial (ICU-Families-Study)
Intensive care unit (ICU) hospitalization is challenging for the family members of the patients. Most family members report some level of anxiety and depression, sometimes even resulting in post-traumatic stre...
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Article
Open AccessComment on: Association between intrarenal venous flow from Doppler ultrasonography and acute kidney injury in patients with sepsis in critical care: a prospective, exploratory observational study
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Chapter and Conference Paper
Event Reconstruction for Neutrino Telescopes
Neutrino telescopes, such as IceCube or KM3NeT, consist of thousands of photo sensors distributed over cubic kilometer volumes. The Cherenkov light from particle interactions within creates signals of varying ...
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Article
Open AccessParallelizing MCMC sampling via space partitioning
Efficient sampling of many-dimensional and multimodal density functions is a task of great interest in many research fields. We describe an algorithm that allows parallelizing inherently serial Markov chain Mo...
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Article
Open AccessFast and precise model calculation for KATRIN using a neural network
We present a fast and precise method to approximate the physics model of the Karlsruhe Tritium Neutrino (KATRIN) experiment using a neural network. KATRIN is designed to measure the effective electron anti-neu...
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Article
Open AccessAntifungal prophylaxis for prevention of COVID-19-associated pulmonary aspergillosis in critically ill patients: an observational study
Coronavirus disease 19 (COVID-19)-associated pulmonary aspergillosis (CAPA) emerged as important fungal complications in patients with COVID-19-associated severe acute respiratory failure (ARF). Whether mould ...
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Article
Open AccessSoluble urokinase plasminogen activator receptor (suPAR) predicts critical illness and kidney failure in patients admitted to the intensive care unit
Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker and risk factor for kidney diseases, with a potential prognostic value in critically ill patients. In this monocentric pros...
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Article
Open AccessPenetration of echinocandins into wound secretion of critically ill patients
Wound infections caused by Candida are life-threatening and difficult to treat. Echinocandins are highly effective against Candida species and recommended for treatment of invasive candidiasis. As penetration of ...
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Article
Open AccessConvalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study
This study aimed to quantify the potential survival benefit of convalescent plasma therapy (CVP) in critically ill patients with acute respiratory failure related to coronavirus disease-2019 (COVID-19).
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Article
Open AccessSuccessful treatment of severe interstitial pneumonia by removal of circulating autoantibodies: a case series
There is only limited clinical data on the benefit of intense immunosuppression in patients with severe interstitial pneumonia associated with autoimmune features or new-onset connective tissue disease.
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Article
Open AccessSuPAR levels in BAL fluid from patients with acute respiratory distress syndrome—a pilot study
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Article
Open AccessResponse to “COVID-19 in persons with haematological cancers”
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Article
Open AccessAccuracy and stability of an arterial sensor for glucose monitoring in a porcine model using glucose clamp technique
Intravascular glucose sensors have the potential to improve and facilitate glycemic control in critically ill patients and might overcome measurement delay and accuracy issues. This study investigated the accu...
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Article
Open AccessEfficacy, immunogenicity, and safety of IC43 recombinant Pseudomonas aeruginosa vaccine in mechanically ventilated intensive care patients—a randomized clinical trial
Pseudomonas aeruginosa infections are a serious threat in intensive care units (ICUs). The aim of this confirmatory, randomized, multicenter, placebo-controlled, double-blind, phase 2/3 study was to assess the ef...
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Article
Open AccessThe conundrum of postpartum thrombotic Microangiopathy: case report and considerations for management
Microangiopathic hemolytic anemias and thrombocytopenias in pregnant or postpartum women constitute an interdisciplinary diagnostic and therapeutic challenge in the evaluation of thrombotic microangiopathies (...