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Open AccessHow many authors are (too) many? A retrospective, descriptive analysis of authorship in biomedical publications
Publishing in academic journals is primary to disseminate research findings, with authorship reflecting a scientist’s contribution, yielding academic recognition, and carrying significant financial implication...
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Physiologie und Pathophysiologie der Nieren und Harnleiter
Die Nieren dienen der homöostatischen Einstellung und Aufrechterhaltung eines bedarfsadäquaten Wasser-, Salz-, Elektrolyt- und Säure-Basen-Haushalts. Sie eliminieren einerseits harnpflichtige Substanzen und be...
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Living Reference Work Entry In depth
Physiologie und Pathophysiologie der Nieren und Harnleiter
Die Nieren dienen der homöostatischen Einstellung und Aufrechterhaltung eines bedarfsadäquaten Wasser-, Salz-, Elektrolyt- und Säure-Basen-Haushalts. Sie eliminieren einerseits harnpflichtige Substanzen und be...
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Article
Open AccessThe green tea catechin epigallocatechin gallate induces cell cycle arrest and shows potential synergism with cisplatin in biliary tract cancer cells
The green tea catechin epigallocatechin gallate (EGCG) was shown to effectively inhibit tumor growth in various types of cancer including biliary tract cancer (BTC). For most BTC patients only palliative thera...
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Glycine modulates membrane potential, cell volume, and phagocytosis in murine microglia
Phagocytes form engulfment pseudopodia at the contact area with their target particle by a process resembling cell volume (CV) regulatory mechanisms. We evaluated whether the osmoregulatory active neutral amin...
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Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
Hereditary hemochromatosis and transfusional iron overload are frequent clinical conditions associated with progressive iron accumulation in parenchymal tissues, leading to eventual organ failure. We have disc...
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Letter to the Editor: Sequence-specific resonance assignments of ICln, an ion channel cloned from epithelial cells
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Article
ICln channels reconstituted in heart-lipid bilayer are selective to chloride
ICln is an ion channel cloned from renal epithelial cells. The reconstitution of the protein in 1,2-diphytanoyl-sn-glycero-3-phosphocholine (Diph-PC) bilayer membranes reveals potassium-selective channels, which...
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Article
Functional reconstitution of ICln in lipid bilayers
Reconstitution of purified ICln in lipid bilayer leads to functional ion channels showing varying rectification. The reconstituted single channels have a conductance of ≅3 pS and their open probability is sen...