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Article
Open AccessDevelo** centrifugal force real-time digital PCR for detecting extremely low DNA concentration
Digital PCR (dPCR) is a technique for absolute quantification of nucleic acid molecules. To develop a dPCR technique that enables more accurate nucleic acid detection and quantification, we established a novel...
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Article
Open AccessThe secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation
Akkermansia muciniphila has received great attention because of its beneficial roles in gut health by regulating gut immunity, promoting intestinal epithelial development, and improving barrier integrity. However...
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Article
Open AccessGlutamine-mediated epigenetic regulation of cFLIP underlies resistance to TRAIL in pancreatic cancer
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent because it kills cancer cells while sparing normal cells. However, many cancers, including pancreatic ductal aden...
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Article
Open AccessEvaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from Angelica sinensis, Ligusticum chuanxiong, and Peaonia lactiflora
HemoHIM G is a functional food ingredient composed of a triple herbal combination of Angelica sinensis, Ligusticum chuanxiong, and Paeonia lactiflora, to improve impaired immune function. Considering the pharmaco...
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Article
Open AccessIdentification of potential biomarkers related to mesenchymal stem cell response in patients with Alzheimer’s disease
Preclinical studies showed that mesenchymal stem cells (MSCs) ameliorate tau phosphorylation, amyloid-beta accumulation, and inflammation in Alzheimer’s disease (AD) mouse models via secretion of neurotrophic ...
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Article
Open AccessSOX17-mediated LPAR4 expression plays a pivotal role in cardiac development and regeneration after myocardial infarction
Lysophosphatidic acid receptor 4 (LPAR4) exhibits transient expression at the cardiac progenitor stage during pluripotent stem cell (PSC)-derived cardiac differentiation. Using RNA sequencing, promoter analyse...
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Article
Open AccessTRPV1 inhibition overcomes cisplatin resistance by blocking autophagy-mediated hyperactivation of EGFR signaling pathway
Cisplatin resistance along with chemotherapy-induced neuropathic pain is an important cause of treatment failure for many cancer types and represents an unmet clinical need. Therefore, future studies should pr...
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Article
Comparison of isolated respiratory and extrarespiratory mucormycosis: a 21-year observational study of 44 cases
This study aimed to compare the clinical characteristics and outcomes of patients with isolated respiratory and extrarespiratory mucormycosis.
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Article
Effects of Pilger Rolling and Heat Treatment on Microstructure and Corrosion Resistance of Ag-Electroplated 304 Stainless Steel Tubes
We introduce a cost-effective method that combines electroplating with metal cold working processes to manufacture composite tubes with robust corrosion resistance. First, a 3-step electroplating process was d...
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Article
Open AccessNANOG confers resistance to complement-dependent cytotoxicity in immune-edited tumor cells through up-regulating CD59
Cancer immunoediting drives the adaptation of tumor cells to host immune surveillance. Previously, we have demonstrated that immunoediting driven by cytotoxic T lymphocytes (CTLs) enriches NANOG+ tumor cells with...
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Article
Open AccessAuthor Correction: Deep learning method for comet segmentation and comet assay image analysis
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Article
The Relationship Between the Zonal Index and Annular Mode Index in Reanalysis and CMIP5 Models
The annular mode at the surface, referred to as the Arctic Oscillation (AO) in the Northern Hemisphere and the Antarctic Oscillation (AAO) in the Southern Hemisphere, is statistically defined by the leading mo...
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Article
Study on Microstructure and Mechanical Properties of the Al–25Cr–5Si (at%) Alloy Powder Using Gas-Atomization and SPS Process
In order to investigate the microstructure and mechanical properties on Al–25Cr–5Si (at%) alloy, a mixed powder with pure elements and an alloy powder using a gas atomization process were used. Fine and high p...
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Article
Optical and Electrical Properties of Multilayer Grid Electrodes for Highly Durable Transparent Conductive Electrodes
We report on the optical and electrical properties of MgZnO/Ag/MgZnO (MAM) grid electrodes grown at room temperature; these are proposed as an alternative to metal-based grid electrodes to meet the requirement...
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Article
Open AccessDeep learning method for comet segmentation and comet assay image analysis
Comet assay is a widely used method, especially in the field of genotoxicity, to quantify and measure DNA damage visually at the level of individual cells with high sensitivity and efficiency. Generally, compu...
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Article
Vitexin enhances osteoblast differentiation through phosphorylation of Smad and expression of Runx2 at in vitro and ex vivo
Vitexin (apigenin-8-C-d-glucopyranoside) is a flavonoid isolated from natural sources. It has been employed as an anti-oxidant, anti-inflammatory, and anti-cancer agent, and is used as a traditional Chinese me...
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Article
Metabolomic profiling of bloodstains on various absorbent and non-absorbent surfaces
Bloodstains found at crime scenes contain immense information about the crime; thus, studies involving analysis of small molecules in bloodstains have been conducted. However, most of these studies have not ac...
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Article
Open AccessEffect of Daesiho-tang on obesity with non-alcoholic fatty liver disease: a study protocol for a randomised, double-blind, placebo-controlled pilot trial
The high prevalence of obesity and non-alcoholic fatty acid disease has become an important public health problem. Daesiho-tang (DST) is an herbal medicine widely used to treat obesity, metabolic syndrome and liv...
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Article
Three-Dimensional Spheroid Formation of Cryopreserved Human Dental Follicle-Derived Stem Cells Enhances Pluripotency and Osteogenic Induction Properties
Enhancement and maintenance of the stemness of mesenchymal stem cells (MSCs) is one of the most important factors contributing to the successful in vivo therapeutic application of these cells. In this regard, thr...
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Article
Open AccessTargeting CYP4A attenuates hepatic steatosis in a novel multicellular organotypic liver model
Non-alcoholic fatty liver disease (NAFLD) begins as simple hepatic steatosis, but further progress to chronic liver diseases results in severe liver damage and hepatic failure. However, therapeutic options are...
