844 Result(s)

Article

Dexmedetomidine and argon in combination against ferroptosis through tackling TXNIP-mediated oxidative stress in DCD porcine livers

Graft availability from donation after circulatory death (DCD) is significantly limited by ischaemia reperfusion (IR) injury. Effective strategies to mitigate IR injury in DCD grafts are essential to improve g...

Qian Chen, Jiashi Sun, **angfeng Liu, Zhigang Qin, Jieyu Li… in Cell Death Discovery (2024)

Article

Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

Hong Xue, Zhenhua Feng, Putao Yuan, Li Qiao, Qiliang Lou… in Cell Death Discovery (2024)

Article

The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis

Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is limited by its various side effects and resistance to chemotherapy. The ...

Wenpeng Zhao, Liwei Zhou, Wentao Zhao, Huiying Yang, Zhenwei Lu… in Cell Death Discovery (2024)

Article

Publisher Correction: LINC317.5 as a novel biomarker for hypertriglyceridemia in abnormal glucose metabolism

Yixue Yang, Mengzi Sun, Shoumeng Yan, Nan Yao, **aotong Li… in Cell Death Discovery (2024)

Article

Correction: Dysfunction of ATG7-dependent autophagy dysregulates the antioxidant response and contributes to oxidative stress-induced biological impairments in human epidermal melanocytes

Zhuhui Qiao, Zhongyi Xu, Qing **ao, Yiwen Yang, Jiayi Ying… in Cell Death Discovery (2024)

Article

The emerging role of nuclear receptor coactivator 4 in health and disease: a novel bridge between iron metabolism and immunity

Nuclear receptor coactivator 4 (NCOA4) has recently been recognized as a selective cargo receptor of ferritinophagy participating in ferroptosis. However, NCOA4 is also a coactivator that modulates the transcr...

Yue Le, Qinjie Liu, Yi Yang, Jie Wu in Cell Death Discovery (2024)

Article

A pan-KRAS degrader for the treatment of KRAS-mutant cancers

KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...

Jie Yang, Qiao-Li Wang, Guan-Nan Wang, Jia-Cong Ye, Zi-Qian Li… in Cell Discovery (2024)

Article

Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma

Lymph node metastasis (LNM) facilitates distant tumor colonization and leads to the high mortality in patients with intrahepatic cholangiocarcinoma (ICC). However, it remains elusive how ICC cells subvert immu...

Bao-Ye Sun, Zhu-Tao Wang, Ke-Zhu Chen, Yang Song, **g-Fang Wu… in Cell Death Discovery (2024)

Article

Structural and functional insights into the helicase protein E5 of Mpox virus

Mpox virus (MPXV) can cause mpox in humans. Due to its quick and wide spread in the past two years, mpox has turned into a significant public health concern. Helicase E5 is a multi-domain protein; its primer s...

Weizhen Zhang, Yusong Liu, Mengquan Yang, Jie Yang, Zhiwei Shao… in Cell Discovery (2024)

Article

Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15

Zhongyuan Zhang, You Zheng, Lu Xu, Yang Yue, Kexin Xu, Fei Li, Fei Xu in Cell Discovery (2024)

Article

LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism

LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed ...

Zhan Liu, Kexin Fan, Aikedaimu Abudukeremu, Min Gao, **nyue Tan… in Cell Death Discovery (2024)

Article

CCL11 released by GSDMD-mediated macrophage pyroptosis regulates angiogenesis after hindlimb ischemia

Peripheral vascular disease (PVD) is an emerging public health burden with a high rate of disability and mortality. Gasdermin D (GSDMD) has been reported to exert pyroptosis and play a critical role in the pat...

Yiwen Wang, Yang Gao, Huairui Shi, Rifeng Gao, Ji’e Yang, Ya’nan Qu… in Cell Death Discovery (2024)

Article

TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling

Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...

Chen Zhang, Fang Tong, Bin Zhou, Mingdong He, Shuai Liu, **aomeng Zhou… in Cell Discovery (2024)

Article

Lactylation of NAT10 promotes N⁴‐acetylcytidine modification on tRNA^Ser-CGA-1-1 to boost oncogenic DNA virus KSHV reactivation

N⁴-acetylcytidine (ac⁴C), a conserved but recently rediscovered RNA modification on tRNAs, rRNAs and mRNAs, is catalyzed by N-acetyltransferase 10 (NAT10). Lysine acylation is a ubiquitous protein modification th...

Qin Yan, **g Zhou, Yang Gu, Wen**g Huang, Mingpeng Ruan… in Cell Death & Differentiation (2024)

Article

Heat shock protein 90α reduces CD8⁺ T cell exhaustion in acute lung injury induced by lipopolysaccharide

CD8⁺ T-cell exhaustion is a promising prognostic indicator of sepsis-induced acute respiratory distress syndrome (ARDS). Patients with sepsis-related ARDS had reduced levels of HSP90AA1. However, whether the chan...

Lei Yan, Yumei Chen, Yilin Yang, Yi Han, Chaoyang Tong in Cell Death Discovery (2024)

Article

A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma

The oncogenic potential of chromosome 8q22 copy number gain in liver cancer remains to be depicted. Here, we report that ZNF706, encoded by a gene mapped to chromosome 8q22, is a C2H2-type zinc finger protein....

Jie Chu, Jun Jiang, **n Fan, Jun Liu, Ke Gao, Yu Jiang… in Cell Death & Differentiation (2024)

Article

Single-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma

Conjunctival melanoma (CoM) is a potentially devastating tumor that can lead to distant metastasis. Despite various therapeutic strategies for distant metastatic CoM, the clinical outcomes remain unfavorable. ...

Hanhan Shi, Hao Tian, Tianyu Zhu, Qili Liao, Chang Liu, Peng Yuan… in Cell Discovery (2024)

Article

Nurturing gut health: role of m6A RNA methylation in upholding the intestinal barrier

The intestinal lumen acts as a critical interface connecting the external environment with the body’s internal state. It’s essential to prevent the passage of harmful antigens and bacteria while facilitating n...

Shuaijie Wang, Yuzhong Yang, **aohan Jiang, **ang Zheng… in Cell Death Discovery (2024)

Article

Hypoxia-induced epigenetic regulation of miR-485-3p promotes stemness and chemoresistance in pancreatic ductal adenocarcinoma via SLC7A11-mediated ferroptosis

The mechanism of hypoxia in chemoresistance of pancreatic ductal adenocarcinoma (PDAC) remains elusive. In this study, we revealed the essential role of miR-485-3p in PDAC, particularly its impact on cancer st...

**nxin Liu, Zhihua Huang, Qiuzheng Chen, Kai Chen, Weikang Liu… in Cell Death Discovery (2024)

Article

A novel mutation of DNA2 regulates neuronal cell membrane potential and epileptogenesis

Mesial temporal lobe epilepsy (MTLE) is one of the most intractable epilepsies. Previously, we reported that mitochondrial DNA deletions were associated with epileptogenesis. While the underlying mechanism of ...

Yuting Liu, Haiyan Yang, Siyi Gan, Lu He, Rongrong Zeng, Ting **ao… in Cell Death Discovery (2024)