24 Result(s)

Article

Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15

Zhongyuan Zhang, You Zheng, Lu Xu, Yang Yue, Kexin Xu, Fei Li, Fei Xu in Cell Discovery (2024)

Article

Exploration of the potential association between GLP-1 receptor agonists and suicidal or self-injurious behaviors: a pharmacovigilance study based on the FDA Adverse Event Reporting System database

Establishing whether there is a potential relationship between glucagon-like peptide 1 receptor agonists (GLP-1RAs) and suicidal or self-injurious behaviors (SSIBs) is crucial for public safety. This study inv...

Jianxing Zhou, You Zheng, Baohua Xu, Songjun Long, Li-e Zhu, Yunhui Liu… in BMC Medicine (2024)

Article

One-year follow-up study after patients with severe COVID-19 received human umbilical cord mesenchymal stem cells treatment

The novel coronavirus is still mutating, and the pandemic continues. Meanwhile, many COVID-19 survivors have residual postinfection clinical manifestations. Human umbilical cord mesenchymal stem cells (hUC-MSC...

Lei Shi, You Zheng, Zhi Cheng, Ningfei Ji, Changming Niu… in Stem Cell Research & Therapy (2022)

Article

Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y

Rodents, such as mice, are vulnerable targets, and potential intermediate hosts, of SARS-CoV-2 variants of concern, including Alpha, Beta, Gamma, and Omicron. N501Y in the receptor-binding domain (RBD) of Spik...

Yichao Zhu, Wenzhao Zhou, Zubiao Niu, Jiayi Sun, Zhengrong Zhang… in Biology Direct (2022)

Article

Cell-in-cell structure mediates in-cell killing suppressed by CD44

Penetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells. We unexpectedly found that CIC formation largely led t...

Yan Su, Hongyan Huang, Tianzhi Luo, You Zheng, Jie Fan, He Ren, Meng Tang… in Cell Discovery (2022)

Article

Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer

Senescence is believed to be a pivotal player in the onset and progression of tumors as well as cancer therapy. However, the guiding roles of senescence in clinical outcomes and therapy selection for patients ...

Lulin Zhou, Zubiao Niu, Yuqi Wang, You Zheng, Yichao Zhu… in Cell Death Discovery (2022)

Article

Cell fusion in the pathogenesis of COVID-19

You Zheng, Lu-Lin Zhou, Yan Su, Qiang Sun in Military Medical Research (2021)

Article

SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is highly contagious and causes lymphocytopenia, but the underlying mechanisms are poorly understood. We demonstrate here that heterotypic...

Zhengrong Zhang, You Zheng, Zubiao Niu, Bo Zhang… in Cell Death & Differentiation (2021)

Article

N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding

Zubiao Niu, Zhengrong Zhang, **aoyan Gao… in Signal Transduction and Targeted Therapy (2021)

Article

Baidu Jieduan granules, traditional Chinese medicine, in the treatment of moderate coronavirus disease-2019 (COVID-19): study protocol for an open-label, randomized controlled clinical trial

Currently, coronavirus disease-2019 (COVID-19) is continuously and rapidly circulating, resulting in serious and extensive effects on human health. Due to the absence of antiviral medicine for COVID-19 thus fa...

Wen Zhang, Qin **e, **aoming Xu, Shuting Sun, Tian Fan, **nxin Wu, Yao Qu… in Trials (2021)

Article

Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in rats

Prenatal synthetic glucocorticoid (sGC) exposure increases the susceptibility to cognitive and affective disorders in postnatal life. We previously demonstrated that prenatal sGC exposure results in an increas...

You Zheng, Yan-Min Zhang, Zheng-Shan Tang, Jian-Kui Du… in Journal of Neuroinflammation (2021)

Article

Role and dynamics of vacuolar pH during cell-in-cell mediated death

The nonautonomous cell death by entosis was mediated by the so-called cell-in-cell structures, which were believed to kill the internalized cells by a mechanism dependent on acidified lysosomes. However, the p...

Yan Su, He Ren, Meng Tang, You Zheng, Bo Zhang, Chenxi Wang… in Cell Death & Disease (2021)

Article

Identification and validation of heterotypic cell-in-cell structure as an adverse prognostic predictor for young patients of resectable pancreatic ductal adenocarcinoma

Hongyan Huang, Meifang He, Yanbin Zhang… in Signal Transduction and Targeted Therapy (2020)

Article

Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells

COVID-19 is a highly infectious respiratory disease. No therapeutics have yet been proven effective for treating severe COVID-19.

Lei Shu, Changming Niu, Ruyou Li, Tingrong Huang, Yan Wang… in Stem Cell Research & Therapy (2020)

Article

Shenhuang granule in the treatment of severe coronavirus disease 2019 (COVID-19): study protocol for an open-label randomized controlled clinical trial

Currently, coronavirus disease 2019 (COVID-19) is continuously and rapidly circulating, causing heavy damage on public health. No effective antiviral treatment has been proved thus far. Traditional Chinese med...

Bangjiang Fang, Wen Zhang, **nxin Wu, Tingrong Huang, Huacheng Li, You Zheng… in Trials (2020)