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Article
Open AccessSingle-cell sequencing depicts tumor architecture and empowers clinical decision in metastatic conjunctival melanoma
Conjunctival melanoma (CoM) is a potentially devastating tumor that can lead to distant metastasis. Despite various therapeutic strategies for distant metastatic CoM, the clinical outcomes remain unfavorable. ...
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Article
Open AccessARID1A loss promotes RNA editing of CDK13 in an ADAR1-dependent manner
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is thought to play a significant role both in tumor suppression and tumor initiation, which is highly dependent upon context. Previous studies hav...
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Article
Open AccessAn improved epigenetic counter to track mitotic age in normal and precancerous tissues
The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to be a major determinant of cancer-risk. Somatic mutational and DNA methylation (DNAm) clocks are promising tools to ...
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Article
Open AccessThe application of improved densenet algorithm in accurate image recognition
Image recognition technology belongs to an important research field of artificial intelligence. In order to enhance the application value of image recognition technology in the field of computer vision and imp...
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Article
Study on creep properties of weak layer rock of slope under damage coupling
Based on the fractional order calculus theory and Weibull distribution, the fractional order nonlinear creep constitutive equation of green mudstone in the weak interlayer of slope under the combined action of...
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Article
Influence of 3D Aggregate Shape on the Meso-Structure of 2D Cross-Sectional Concrete by the Numerical Slicing Method
Aggregate shape is essential for evaluating concrete properties. Most of the existing literature utilizes X-ray computed tomography (X-CT) to assess the morphological characteristics of 2D/3D aggregates. Howev...
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Article
“Polymer in ceramic” type LLZTO/PEO/PVDF composite electrolyte with high lithium migration number for solid-state lithium batteries
One of the effective methods to improve the energy density and safety of lithium metal batteries is to use composite solid electrolytes with high voltage and good performance. However, the low ionic conductivi...
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Article
Cancer-Associated Fibroblast-Secreted Exosomes Promote Gastric Cancer Cell Migration and Invasion via the IL-32/ESR1 Axis
Exosomes secreted by cancer-associated fibroblasts (CAFs) play a critical part in cancer progression. This study aimed to explore the effects of CAF-exosomes on gastric cancer (GC) cell metastasis. AGS and HGC...
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Article
Open AccessSTYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation
Tubulin-based microtubule is a core component of flagella axoneme and essential for sperm motility and male fertility. Structural components of the axoneme have been well explored. However, how tubulin folding...
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Article
Experimental study on the failure of fractured rock slopes with anti-dip and strong weathering characteristics under rainfall conditions
Many landslide events occur during or immediately after rainfall, which is one of the main factors that induce slope instability. In this study, a physical model test was conducted to investigate the hydrologi...
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Article
Open AccessCoupling of Adhesion and Anti-Freezing Properties in Hydrogel Electrolytes for Low-Temperature Aqueous-Based Hybrid Capacitors
A class of hydrogel electrolytes that couple high adhesion and anti-freezing properties is developed.
Zn/Li hybrid capacito...
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Article
microRNA-301b-3p from mesenchymal stem cells-derived extracellular vesicles inhibits TXNIP to promote multidrug resistance of gastric cancer cells
MicroRNAs (miRNAs) from mesenchymal stem cells (MSC)-derived extracellular vesicles (MSCs-EVs), including exosomes, are known to participate in different diseases. However, the function of miR-301b-3p from MSC...
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Article
MYC-targeted genes predict distant recurrence in patients with ocular adnexal extranodal marginal zone lymphoma
Ocular adnexal extranodal marginal zone lymphoma (OA-EMZL) is the most frequent subtype of ocular adnexal lymphoma, with a high propensity for recurrence. Distant recurrence (DR) as an essential prognostic eve...
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Article
Rainfall infiltration and three-dimensional stability analyses of fractured rock slopes considering preferential flow
Rainfall infiltration is one of the main factors inducing landslides. For rock slopes with more developed fractures, the effect of preferential flow cannot be neglected. Thus, this study investigates the effec...
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Article
Risk factors and prognosis of orbital exenteration in conjunctival melanoma
To identify the risk factors of orbital exenteration and to evaluate the prognosis of exenterated patients with conjunctival melanoma (CM).
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Article
Open AccessA meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes
Changes in cell-type composition of tissues are associated with a wide range of diseases and environmental risk factors and may be causally implicated in disease development and progression. However, these shi...
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Article
Open AccessAuto-regressive extractive summarization with replacement
Auto-regressive extractive summarization approaches determine sentence extraction probability conditioning on previous decisions by maintaining a partial summary representation. Despite its popularity, the fra...
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Article
Failure and Fracture Process Characteristics of Layered Slate: Experimental Observation and Discrete Element Modeling
The thin-bedded slate exhibits the characteristics of strong anisotropy is widely found in underground engineering, where its complex fracture behaviors can easily lead to drastic engineering hazards. Therefor...
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Article
Formation of hierarchically ordered structures in conductive polymers to enhance the performances of lithium-ion batteries
Electrically conductive polymers have found increasing applications in energy conversion and storage devices. In the conventional design of conductive polymers, organic functionalities are introduced via botto...
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Article
Combined analysis of stiffness and fatigue life of deep groove ball bearings under interference fits, preloads and tilting moments
The stiffness and fatigue life of deep groove ball bearings are greatly affected by interference fits, preloads and tilting moments. Up to now, most of current works failed to focus on the integrated analysis ...
