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Article
Open AccessAssociation between new Life’s Essential 8 and the risk of all-cause and cardiovascular mortality in patients with hypertension: a cohort study
The American Heart Association recently introduced a new model for cardiovascular health (CVH) known as Life’s Essential 8 (LE8). The impact of LE8 on hypertensive individuals is currently unclear. In our stud...
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Article
Open AccessA novel mutation of DNA2 regulates neuronal cell membrane potential and epileptogenesis
Mesial temporal lobe epilepsy (MTLE) is one of the most intractable epilepsies. Previously, we reported that mitochondrial DNA deletions were associated with epileptogenesis. While the underlying mechanism of ...
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Article
Genomic insights into local adaptation of upland cotton in China and Pakistan
Different kinship and resistance to cotton leaf curl disease (CLCuD) and heat were found between upland cotton cultivars from China and Pakistan. 175 SNPs and 82 InDels loci related to yield, fiber quality, CL...
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Article
Open AccessComparative transcriptomic analysis provides insights into the genetic networks regulating oil differential production in oil crops
Plants differ more than threefold in seed oil contents (SOCs). Soybean (Glycine max), cotton (Gossypium hirsutum), rapeseed (Brassica napus), and sesame (Sesamum indicum) are four important oil crops with markedl...
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Article
Relationship between ischemic index, leakage index, and macular edema in branch retinal vein occlusion
To investigate the combined association of the ischemic index and leakage index with macular edema on ultra-widefield fluorescein angiography (UWFFA) in patients with branch retinal vein occlusion (BRVO).
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Article
Open AccessAutomatic Detection of 30 Fundus Diseases Using Ultra-Widefield Fluorescein Angiography with Deep Experts Aggregation
Inaccurate, untimely diagnoses of fundus diseases leads to vision-threatening complications and even blindness. We built a deep learning platform (DLP) for automatic detection of 30 fundus diseases using ultra...
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Article
Destabilization Mechanism and Prevention Technology of Open-Pit Mine Slope with Soft Interlayer Under Rainfall Infiltration Conditions: A Case Study
There are many factors affecting the stability of open-pit mine slopes, among which slopes with soft interlayers have become an important factor inducing deformation and instability due to their poor mechanica...
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Article
Experimental and Numerical Study of Plug-Holing with Lateral Smoke Exhaust in Tunnel Fires
A series of experiments and simulations were conducted to investigate the effect of lateral smoke exhaust in tunnel fires. A special phenomenon, plug-holing was observed. Combined with the exhaust vent size, h...
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Article
Open AccessNEDD4-2 and the CLC-2 channel regulate neuronal excitability in the pathogenesis of mesial temporal lobe epilepsy
An increasing number of studies have focused on the role of NEDD4-2 in regulating neuronal excitability and the mechanism of epilepsy. However, the exact mechanism has not yet been elucidated. Here, we explored t...
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Article
Display of Lignin Peroxidase on the Surface of Bacillus subtilis
Lignin peroxidase (LiP) has a good application prospect in lignin degradation, environmental treatment, straw feed, and other industries. However, its application is constrained by the high price and low stabi...
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Article
Open AccessHyperbolic photonic topological insulators
Topological photonics provides a new degree of freedom to robustly control electromagnetic fields. To date, most of established topological states in photonics have been employed in Euclidean space. Motivated ...
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Article
Open AccessModel-based analysis of the incidence trends and transmission dynamics of COVID-19 associated with the Omicron variant in representative cities in China
In 2022, Omicron outbreaks occurred at multiple sites in China. It is of great importance to track the incidence trends and transmission dynamics of coronavirus disease 2019 (COVID-19) to guide further interve...
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Article
Open AccessThe effect of leucocytosis on retinopathy of prematurity
Postnatal leukocytosis reflects the general condition of inflammatory. Infection and inflammatory reaction have been proven to affect the occurrence of ROP and other visual dysfunction. Infants with a gestatio...
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Article
Open AccessUnsupervised clustering analysis of comprehensive health status and its influencing factors on women of childbearing age: a cross-sectional study from a province in central China
Most previous studies on women of childbearing age have focused on reproductive health and fertility intentions, and evidence regarding the comprehensive health status of women of childbearing age is limited. ...
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Article
Open AccessCorrection: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma
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Article
The Correlation Between IFNG Gene Methylation and Th1|Th2 Cell Balance in ROU and the Interventional Study of Jiaweidaochi Powder
The pathogenesis of recurrent oral ulcers (ROU) is complex, with a long duration of illness and challenging to cure. According to traditional Chinese medicine (TCM),”heat accumulation in the heart-spleen” is o...
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Article
Open AccessImplications for implementation and adoption of telehealth in develo** countries: a systematic review of China’s practices and experiences
The rapid advancement of telehealth technologies has the potential to revolutionize healthcare delivery, especially in develo** countries and resource-limited settings. Telehealth played a vital role during ...
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Article
Open AccessTackling global health security by building an academic community for One Health action
One Health approach is crucial to tackling complex global public health threats at the interface of humans, animals, and the environment. As outlined in the One Health Joint Plan of Action, the international O...
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Article
Multi-task learning with helpful word selection for lexicon-enhanced Chinese NER
Named entity recognition (NER) is a common task in the field of natural language processing, but it remains more challenging in Chinese due to the lack of natural delimiters. Recently, lots of works incorporat...
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Article
A new method to prepare calcium oxalate films for marble protection
Artificial calcium oxalate films have been applied to protect sculptures, monuments, and buildings made of marble due to their potential protective capacities. Unfortunately, artificially prepared calcium oxal...
