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Open AccessLIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism
LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed ...
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Article
Open AccessU-shaped association between serum calcium and in-hospital mortality in diabetes patients with congestive heart failure: a cohort study
Previous studies have reported that the significant association between serum calcium and mortality substantially in patients, especially among those with intensive care unit (ICU). And In diabetes mellitus, c...
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Article
Open AccessThe efficacy and safety of continuous intravenous infusion of rh-endostatin combined with platinum-based doublet chemotherapy for advanced non-small-cell lung cancer
Platinum-based doublet chemotherapy is commonly used in the treatment of non-small cell lung cancer (NSCLC). A growing body of evidence indicates that incorporating antiangiogenic agents into platinum-based ch...
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Article
Association between serum chloride and in-hospital mortality in congestive heart failure with diabetes: Data from the MIMIC-IV database
Congestive heart failure (CHF) demonstrates a heightened prevalence in individuals with diabetes mellitus within Intensive Care Units. The occurrence of abnormal chloride levels is frequently observed in criti...
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Article
A Hydromechanical Model for a Single Rock Fracture Subjected to Shearing
Accurately predicting the hydromechanical behaviour of rock fractures is challenging due to the significant influence of shear-induced fracture geometries. This work proposes an improved shear-flow model that ...
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Article
Open AccessDistal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence
Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal barrier1–3. T cells, but not innate lymphoid cells, have an indispensable role in sustaining the IL-22 signalling that is requir...
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Article
A new method for preparing permanent flame-retardant lyocell fibre: Preparation of flame-retardant fibres by phosphorylated MTT/lyocell blended fibres
In this study, novel durable flame-retardant lyocell fibres were designed by the addition of phosphorylated cellulose and physical blending of montmorillonite (MTT) within the fibres. The influences of phospho...
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Article
Open AccessReal-time ultrasound-guided sacral plexus block combined with mild sedation for hemorrhoidectomy and hemorrhoidal artery ligation in a patient with amyotrophic lateral sclerosis: a case report
Patients with amyotrophic lateral sclerosis present perioperative challenges for clinical anesthesiologists for anesthesia-associated complications.
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Article
Non-Enzyme, Temperature Calibrating, and Bioactive Fiber-based Flexible Sensors for Dopamine and Lactic Acid Detection
Flexible electrochemical biosensors enable the in-situ monitoring and quantification of human biochemical constituents in molecular scale, spearheading and thriving the field toward precision medicine. However...
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Article
Open AccessGlucose controls lipolysis through Golgi PtdIns4P-mediated regulation of ATGL
Metabolic crosstalk of the major nutrients glucose, amino acids and fatty acids (FAs) ensures systemic metabolic homeostasis. The coordination between the supply of glucose and FAs to meet various physiologica...
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Article
Sintering mechanism and greatly enhanced ionic conductivity of Mo-doped Li7La3Zr2O12 ceramics via a novel covered sintering
Due to the increasingly urgent safety and energy density concerns of lithium-ion batteries, more and more attention has been attracted by the Li7La3Zr2O12 (LLZO)-based solid electrolytes with high ion conductivit...
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Article
Open AccessA comparative study of mono-exponential and advanced diffusion-weighted imaging in differentiating stage IA endometrial carcinoma from benign endometrial lesions
The purpose of the current investigation is to compare the efficacy of different diffusion models and diffusion kurtosis imaging (DKI) in differentiating stage IA endometrial carcinoma (IAEC) from benign endom...
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Open AccessA case series of co-infection in Mycobacterium tuberculosis and other pathogens: insights from nanopore sequencing
Tuberculosis (TB) continues to be a major global health burden, and co-infection with other pathogens further complicates the diagnosis and treatment of this infectious disease. The present retrospective study...
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Article
Asymptotic normality of error density estimator in stationary and explosive autoregressive models
In this paper, we consider the limit distribution of the error density function estimator in the first-order autoregressive models with negatively associated and positively associated random errors. Under mild...
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Article
Early, non-invasive detection of radiation-induced lung injury using PET/CT by targeting CXCR4
Radiation-induced lung injury (RILI) is a severe side effect of radiotherapy (RT) for thoracic malignancies and we currently lack established methods for the early detection of RILI. In this study, we synthesi...
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Article
Simulation studies for the first pathfinder of the CATCH space mission
The Chasing All Transients Constellation Hunters (CATCH) space mission is an intelligent constellation consisting of 126 micro-satellites in three types (A, B, and C), designed for X-ray observation with the o...
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Article
Asymptotic results of error density estimator in nonlinear autoregressive models
This paper considers the asymptotic properties of the error density estimator in the nonlinear autoregressive models with \(\alpha\) ...
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Article
The energy response of LaBr \(_{3}\) (Ce), LaBr \(_{3}\) (Ce,Sr), and NaI(Tl) crystals for GECAM
The GECAM series of satellites utilizes LaBr \(_3\) 3 ...
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Article
An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences
The central mechanisms underlying pain chronicity remain elusive. Here, we identify a reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the ventral tegmental area (VTA) that m...
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Article
Open AccessMETTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation
While liver cancer stem cells (CSCs) play a crucial role in hepatocellular carcinoma (HCC) initiation, progression, recurrence, and treatment resistance, the mechanism underlying liver CSC self-renewal remains...
