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Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression
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Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring
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Open AccessBlockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer
KRAS mutations are present in over 90% of pancreatic ductal adenocarcinomas (PDAC), and drive their poor outcomes and failure to respond to targeted therapies. Here we show that Leukemia Inhibitory Factor (LIF...
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Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of...
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Referral frequency, attrition rate, and outcomes of germline testing in patients with pancreatic adenocarcinoma
Hereditary predisposition is estimated to account for 10% of all pancreatic cancer cases. However, referral patterns and clinical workflow for germline testing in this disease differ significantly by instituti...
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Molecular subtypes of pancreatic cancer
Cancers that appear morphologically similar often have dramatically different clinical features, respond variably to therapy and have a range of outcomes. Compelling evidence now demonstrates that differences ...
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Open AccessCell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma
Sebaceous carcinomas (SeC) are cutaneous malignancies that, in rare cases, metastasize and prove fatal. Here we report whole-exome sequencing on 32 SeC, revealing distinct mutational classes that explain both ...
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Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
Matthew Meyerson, Ramaswamy Govindan and colleagues examine the exome sequences and copy number profiles of 660 lung adenocarcinoma and 484 lung squamous cell carcinoma tumors. They identify novel significantl...
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Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression
Impaired TGF-β signaling due to SMAD4 mutation in PDAC tumors initiates a STAT3-dependent signaling cascade that leads to increased stromal stiffening and disease progression.
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RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK–positive lung cancer
Unraveling the signaling dependencies of EMLK4-ALK fusion–driven lung cancer reveals upfront combination therapy strategies.
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Open AccessErratum to: Modeling precision treatment of breast cancer
During the type-setting of the final version of the article [1] some of the additional files were swapped. The correct files are republished in this Erratum.
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Open AccessCirculating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls
Circulating biomarkers are urgently needed in hepatocellular carcinoma (HCC). The aims of this study were to determine the feasibility of detecting and isolating circulating tumor cells (CTCs) in HCC patients ...
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The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies
Trever Bivona and colleagues show that the Hippo pathway effector YAP promotes resistance to RAF and MEK inhibitor therapy in multiple types of BRAF-mutant tumors. The findings suggest that combined suppression o...
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Open AccessModeling precision treatment of breast cancer
First-generation molecular profiles for human breast cancers have enabled the identification of features that can predict therapeutic response; however, little is known about how the various data types can bes...
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Open AccessA robust prognostic signature for hormone-positive node-negative breast cancer
Systemic chemotherapy in the adjuvant setting can cure breast cancer in some patients that would otherwise recur with incurable, metastatic disease. However, since only a fraction of patients would have recurr...
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Open AccessThe Cancer Genome Atlas Pan-Cancer analysis project
Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities a...
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A colorectal cancer classification system that associates cellular phenotype and responses to therapy
Gene-expression profiles from over 1,000 colorectal tumors define six subtypes with specific phenotypical features, responses to therapy and clinical progression.
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What are we learning from the cancer genome?
The question “are we learning anything new?” keeps being asked when related to comprehensive gene analysis of tumours. This Review attempts to answer that question, and describes how new targets are being iden...
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Timing chromosomal abnormalities using mutation data
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Timing chromosomal abnormalities using mutation data
