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  1. No Access

    Article

    Inactivation of Capicua drives cancer metastasis

    Trever Bivona and colleagues use an in vivo lung cancer metastasis model to show that the transcriptional repressor Capicua (CIC) suppresses invasion and metastasis. CIC inactivation leads to upregulation of ETV4...

    Ross A Okimoto, Frank Breitenbuecher, Victor R Olivas, Wei Wu… in Nature Genetics (2017)

  2. No Access

    Article

    RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK–positive lung cancer

    Unraveling the signaling dependencies of EMLK4-ALK fusion–driven lung cancer reveals upfront combination therapy strategies.

    Gorjan Hrustanovic, Victor Olivas, Evangelos Pazarentzos, Asmin Tulpule… in Nature Medicine (2015)