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Article
Immunology and immunotherapy of cholangiocarcinoma
Cholangiocarcinoma is the second most common primary liver cancer. Its incidence is low in the Western world but is rising globally. Surgery, chemotherapy and radiation therapy have been the only treatment opt...
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Article
Molecular pathogenesis and systemic therapies for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers. The poor outcome associated with HCC is dramatically changing due to the advent of effective systemic therapies. Here we ...
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Article
Open AccessComparative Efficacy of Cabozantinib and Regorafenib for Advanced Hepatocellular Carcinoma
No trials have compared cabozantinib and regorafenib for the second-line treatment of advanced hepatocellular carcinoma (HCC).
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Article
Harnessing big ‘omics’ data and AI for drug discovery in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common form of primary adult liver cancer. After nearly a decade with sorafenib as the only approved treatment, multiple new agents have demonstrated efficacy in clin...
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Article
Publisher Correction: Harnessing big ‘omics’ data and AI for drug discovery in hepatocellular carcinoma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Vitamin D Levels in Patients with Colorectal Cancer Before and After Treatment Initiation
We aimed to described 25-hydroxyvitamin D [25(OH)D] levels in newly diagnosed colorectal cancer (CRC) patients and to re-evaluate levels after chemotherapy.
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Article
Open AccessImmunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the p...
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Article
Cholangiocarcinoma — evolving concepts and therapeutic strategies
Each anatomical subtype of cholangiocarcinoma, intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA), has a distinct epidemiology, biology, and prognosis, thus necessitating...
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Article
Cases of Spontaneous Tumor Regression in Hepatobiliary Cancers: Implications for Immunotherapy?
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Article
Open AccessCirculating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls
Circulating biomarkers are urgently needed in hepatocellular carcinoma (HCC). The aims of this study were to determine the feasibility of detecting and isolating circulating tumor cells (CTCs) in HCC patients ...
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Article
Erratum to: A Simple and Sensitive LC–MS/MS Method for Simultaneous Determination of Temsirolimus and Its Major Metabolite in Human Whole Blood
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Article
A Simple and Sensitive LC–MS/MS Method for Simultaneous Determination of Temsirolimus and Its Major Metabolite in Human Whole Blood
A simple, fast and sensitive LC–MS/MS method was developed and validated for the simultaneous determination of the concentrations of temsirolimus and its major metabolite, sirolimus, in human whole blood. The ...
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Article
Drug development in advanced colorectal cancer: Challenges and opportunities
Despite recent advances in treatment options, advanced colorectal cancer (ACC) remains a leading cause of cancer death worldwide, and new therapies are needed to improve the grim prognosis of this disease. Dru...
