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Open AccessAuthor Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
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Publisher Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessEther phospholipids are required for mitochondrial reactive oxygen species homeostasis
Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The contributions of mitochondrial metabolism to tumo...
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Open AccessCompound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway
Nuclear factor erythroid 2-related factor 2 (NRF2) is aberrantly activated in about 93% of pancreatic cancers. Activated NRF2 regulates multiple downstream molecules involved in cancer cell metabolic reprogram...
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Open AccessA user guide for the online exploration and visualization of PCAWG data
The Pan-Cancer Analysis of Whole Genomes (PCAWG) project generated a vast amount of whole-genome cancer sequencing resource data. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Con...
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Open AccessAssessment of Luminal and Basal Phenotypes in Bladder Cancer
Genomic profiling studies have demonstrated that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors and sensitivities to frontline chemo...
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Open AccessComprehensive molecular characterization of mitochondrial genomes in human cancers
Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Conso...
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Integrated transcriptomic–genomic tool Texomer profiles cancer tissues
Profiling of both the genome and the transcriptome promises a comprehensive, functional readout of a tissue sample, yet analytical approaches are required to translate the increased data dimensionality, hetero...
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Open AccessElemCor: accurate data analysis and enrichment calculation for high-resolution LC-MS stable isotope labeling experiments
The investigation of intracellular metabolism is the mainstay in the biotechnology and physiology settings. Intracellular metabolic rates are commonly evaluated using labeling pattern of the identified metabol...
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Open AccessGlobal analysis of tRNA and translation factor expression reveals a dynamic landscape of translational regulation in human cancers
The protein translational system, including transfer RNAs (tRNAs) and several categories of enzymes, plays a key role in regulating cell proliferation. Translation dysregulation also contributes to cancer deve...
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Open AccessClinical significance of FBXO17 gene expression in high-grade glioma
High-grade gliomas (HGGs) exhibit marked heterogeneity in clinical behavior. The purpose of this study was to identify a novel biomarker that predicts patient outcome, which is helpful in HGG patient management.
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Genomic Assessment of Muscle-Invasive Bladder Cancer: Insights from the Cancer Genome Atlas (TCGA) Project
Invasive bladder cancer is a major medical problem associated with metastatic disease and frequent mortality. Although previous studies had identified many genetic alterations in invasive bladder cancer, recen...
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Open AccessExpression of human endogenous retrovirus-K is strongly associated with the basal-like breast cancer phenotype
Human endogenous retroviruses (HERVs), which make up approximately 8% of the human genome, are overexpressed in some breast cancer cells and tissues but without regard to cancer subtype. We, therefore, analyze...
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Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
Matthew Meyerson, Ramaswamy Govindan and colleagues examine the exome sequences and copy number profiles of 660 lung adenocarcinoma and 484 lung squamous cell carcinoma tumors. They identify novel significantl...
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TransVar: a multilevel variant annotator for precision genomics
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Correction: Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas
Nature Communications 5: Article number: 3887 (2014); Published 29 May 2014; Updated 28 Jan 2015 This Article contains an error in the Author contributions section that has resulted in incorrect credit for sup...
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Open AccessGenes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial–mesenchymal transition
DNA methylation is associated with aberrant gene expression in cancer, and has been shown to correlate with therapeutic response and disease prognosis in some types of cancer. We sought to investigate the biol...
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Open AccessTargeted metabolomic analysis of amino acid response to L-asparaginase in adherent cells
L-asparaginase (L-ASP) is a therapeutic enzyme used clinically for the treatment of childhood acute lymphoblastic leukemia. L-ASP’s anticancer activity is believed to be associated primarily with depletion of ...
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Assessing the clinical utility of cancer genomic and proteomic data across tumor types
For several cancer types analyzed by The Cancer Genome Atlas project, predictions of patient survival were not substantially improved by using common data mining approaches to combine traditional clinical vari...
