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  1. Article

    Open Access

    Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma

    Pancreatic cancer is characterized by extensive resistance to conventional therapies, making clinical management a challenge. Here we map the epigenetic dependencies of cancer stem cells, cells that preferenti...

    L. Paige Ferguson, Jovylyn Gatchalian, Matthew L. McDermott… in Nature Communications (2023)

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  2. No Access

    Protocol

    Single-Cell Transcriptomic and Epigenetic Analyses of Mouse Mammary Development Starting with the Embryo

    Cancers are caricatures of normal development. Yet, for most organs we are only beginning to learn about the molecular events underlying the embryonic antecedents of organogenesis and when differentiation into...

    Zhibo Ma, Nikki K. Lytle, Cynthia Ramos, Razia F. Naeem… in Mammary Stem Cells (2022)

  3. Article

    Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

    Yu Shi, Weina Gao, Nikki K. Lytle, Peiwu Huang, **ao Yuan, Amanda M. Dann… in Nature (2021)

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  4. No Access

    Article

    Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

    Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of...

    Yu Shi, Weina Gao, Nikki K. Lytle, Peiwu Huang, **ao Yuan, Amanda M. Dann… in Nature (2019)

  5. No Access

    Article

    Stem cell fate in cancer growth, progression and therapy resistance

    Although we have come a long way in our understanding of the signals that drive cancer growth, and how these signals can be targeted, effective control of this disease remains a key scientific and medical chal...

    Nikki K. Lytle, Alison G. Barber, Tannishtha Reya in Nature Reviews Cancer (2018)

  6. No Access

    Article

    Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma

    The stem cell determinant Musashi (Msi) is a key mediator of pancreatic cancer progression and therapy resistance.

    Raymond G. Fox, Nikki K. Lytle, Dawn V. Jaquish, Frederick D. Park, Takahiro Ito… in Nature (2016)