16 Result(s)
within
Dennis D. Taub
Biomedicine
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Article
Tellurium Compound AS101 Ameliorates Experimental Autoimmune Encephalomyelitis by VLA-4 Inhibition and Suppression of Monocyte and T Cell Infiltration into the CNS
Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS) involving demyelinating and neurodegenerative processes. Several of the major pathological CNS alterations and ...
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Article
Open AccessDifferential G protein subunit expression by prostate cancer cells and their interaction with CXCR5
Prostate cancer (PCa) cell lines and tissues differentially express CXCR5, which positively correlate with PCa progression, and mediate PCa cell migration and invasion following interaction with CXCL13. Howeve...
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Article
Open AccessControlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production
Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled ...
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Article
Open AccessCXCL10 blockade protects mice from cyclophosphamide-induced cystitis
Alterations in serum CXCR3 ligand levels were examined in interstitial cystitis (IC) patients; similar expression patterns in serum as well as CXCR3, CXCR3 ligands, and cytokines expressed by peripheral and lo...
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Article
Open AccessCXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis
The role of Mycobacteria in the etiology of Crohn's disease (CD) has been a contentious subject for many years. Recently, our laboratory showed that spontaneous colitis in IL-10-/- mice is driven in part by antig...
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Article
Open AccessThe Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production
We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-γ and TNF-α expression by activated human T cells ...
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Article
Open AccessDirect and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes
Vitamin A (VA) deficiency induces a type 1 cytokine response and exogenously provided retinoids can induce a type 2 cytokine response both in vitro and in vivo. The precise mechanism(s) involved in this phenotypi...
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Article
Ancient viral protein enrages astrocytes in multiple sclerosis
Syncytin is a viral envelope protein encoded in the human genome. New work in this issue indicates that it is activated in multiple sclerosis astrocytes and microglia, contributing to the inflammation-induced ...
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Article
Open AccessAge-associated alterations in CXCL1 chemokine expression by murine B cells
The CXCL1 chemokines, macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant (KC), have been shown to play a role in a number of pathophysiological disease states including e...
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Article
Gene Expression Profiling: From Microarrays to Medicine
With the map** of the human genome comes the ability to identify genes of interest in specific diseases and the pathways involved therein. Laboratory technology has evolved in parallel, providing us with the...
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Article
Open AccessQuantitative differences in lipid raft components between murine CD4+ and CD8+ T cells
Lipid rafts have been shown to play a role in T cell maturation, activation as well as in the formation of immunological synapses in CD4+ helper and CD8+ cytotoxic T cells. However, the differential expression of...
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Protocol
Modified Microchemotaxis Assays
Chemotaxis is the process by which leukocytes are directed to sites of inflammation under the influence of a concentration gradient of the soluble chemotactic molecules. Upon encountering a chemotactic molecul...
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Article
Microarray analysis of chemokines, chemokine receptors and related pathways
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Chapter
Natural Killer Cell-Chemokine Interactions
The process of inflammation and immune recognition involve a complex series of events that result in an accumulation of specific leukocyte subsets at the site of tissue alteration or damage. These processes in...
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Chapter
The Effects of Human Recombinant MIP-1α, MIP-1β, and Rantes on the Chemotaxis and Adhesion of T Cell Subsets
Different members of the chemokine superfamily chemoattract and activate specific leukocyte subsets. For example, IL-8 predominantly chemoattracts neutrophils in vivo, while MCAF is selectively chemotactic for...
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Chapter
The Effect of Morphine and Dago on the Proliferative Response of Murine Splenocytes
There is an increasing body of evidence supporting the existence of a neural-immune network in which endogenous opioids play a role as mediators (1–3). Endogenous opioids have been shown to have a number of im...
