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Article
TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4+Foxp3+ regulatory T cells
TNFR2 expression is a characteristic of highly potent immunosuppressive tumor infiltrating CD4+Foxp3+ regulatory T cells (Tregs). There is compelling evidence that TNF through TNFR2 preferentially stimulates the ...
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Article
Open AccessInhibition of murine hepatoma tumor growth by cryptotanshinone involves TLR7-dependent activation of macrophages and induction of adaptive antitumor immune defenses
Cryptotanshinone (CT), a purified compound initially isolated from the dried roots of Salvia militorrhiza. Bunge, exhibits cytotoxic antitumor effects on many tumors. We have shown that CT possesses the dual cap...
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Article
Open AccessCryptotanshinone has curative dual anti-proliferative and immunotherapeutic effects on mouse Lewis lung carcinoma
Lung cancer is currently the leading cause of cancer-related mortality with very limited effective therapy. Screening of a variety of traditional Chinese medicines (TCMs) for their capacity to inhibit the prol...
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Article
Open AccessCombined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice
Transient depletion of CD4+ T cells results in tumor suppression and survival benefit in murine models; however, the tumor progression and recurrence still occur over more long-term monitoring of mice. Thus, we e...
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Article
Open AccessDevelopment of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors
Harnessing immune system to treat cancer requires simultaneous generation of tumor-specific CTLs and curtailment of tumor immunosuppressive environment. Here, we developed an immunotherapeutic regimen capable ...
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Article
Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity
Adalimumab, an anti-TNF monoclonal antibody used to treat rheumatoid arthritis and other autoimmune disorders, paradoxically enhances the capacity of TNF to expand TNF receptor type II-expressing regulatory T ...
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Article
Open AccessCorrection: Corrigendum: TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis
Scientific Reports 6: Article number: 32834; published online: 07 September 2016; updated: 13 October 2016
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Article
Open AccessTNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis
There is now compelling evidence that TNFR2 is constitutively expressed on CD4+ Foxp3+ regulatory T cells (Tregs) and TNF-TNFR2 interaction is critical for the activation, expansion and functional stability of Tr...
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Article
Suppressive activity of human regulatory T cells is maintained in the presence of TNF
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Article
Characterization of MT-2 cells as a human regulatory T cell-like cell line
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Chapter and Conference Paper
Alarmins Initiate Host Defense
In response to infection and/or tissue injury, cells of the host innate immune system rapidly produce a variety of structurally distinct mediators (we elect to call alarmins) that not only function as potent e...
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Chapter
Crosstalk between chemokine, opioid, and vanilloid receptors
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Chapter
Biology of chemokines
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Article
Temporin/VesCP (T/V)-like antibiotic peptides, derived from frogs and wasps, induce migration of human monocytes and neutrophils
Several naturally occurring antimicrobial peptides, from mammals and insects, have previously been shown to be chemotactic for human inflammatory cells. Based on this evidence, ten synthetic analogs of natural...
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Article
Chemokine receptors on dendritic cells promote autoimmune reactions
This paper presents a brief review of several lines of evidence suggesting that chemokine receptors on dendritic cells play an important role in breaking tolerance to self and in inducing autoimmunity. First, ...
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Article
Cytokines: Past, Present, and Future
This review provides an historical account of the discovery and development of cytokines. Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers ...
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Chapter
Interactions of Opioid Receptors, Chemokines, and Chemokine Receptors
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Article
Chemokines as Molecular Targets for Therapeutic Intervention
Despite the youth of the chemokine field, many antagonists of chemokine function have already been identified and tested at the preclinical level. These include neutralizing antibodies, peptidyl and non-peptid...
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Article
New Insights into the Biology of the Acute Phase Response
Innate or natural immunity is a highly conserved defense mechanism against infection found in all multicellular organisms. The acute phase response is the set of immediate inflammatory responses initiated by p...
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Chapter
Chemokine Modulation of Tumor Cell Physiology
Leukocyte infiltration into inflamed or injured tissues is regulated by a variety of cell-associated and soluble factors that mediate the communications between circulating leukocytes and vascular endothelial ...
