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Article
Open AccessMolecular and metabolomic changes in the proximal colon of pigs infected with Trichuris suis
The pig whipworm Trichuris suis is important in swine production because of its negative effects on pig performance and, notably, to some humans with inflammatory bowel disease as a therapeutic agent that modulat...
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Article
Open AccessThe porcine translational research database: a manually curated, genomics and proteomics-based research resource
The use of swine in biomedical research has increased dramatically in the last decade. Diverse genomic- and proteomic databases have been developed to facilitate research using human and rodent models. Current...
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Article
Understanding the host-adapted state of Citrobacter rodentium by transcriptomic analysis
Citrobacter rodentium (Cr) is a mouse pathogen that mimics many aspects of enteropathogenic Escherichia coli infections including producing attaching and effacing (A/E) lesions. Host-adap...
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Article
Open AccessStructural and functional annotation of the porcine immunome
The domestic pig is known as an excellent model for human immunology and the two species share many pathogens. Susceptibility to infectious disease is one of the major constraints on swine performance, yet the...
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Article
Open AccessAnalyses of pig genomes provide insight into porcine demography and evolution
For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and...
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Article
Acute effects of all-trans-retinoic acid in ischemic injury
All-trans-retinoic acid (ATRA) is a vitamin A derivative that is important in neuronal patterning, survival, and neurite outgrowth. Neuroprotective effects of ATRA in ischemia have been demonstrated but its effec...
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Article
Open AccessThe Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production
We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-γ and TNF-α expression by activated human T cells ...
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Article
Open AccessGreen tea increases anti-inflammatory tristetraprolin and decreases pro-inflammatory tumor necrosis factor mRNA levels in rats
Tristetraprolin (TTP/ZFP36) family proteins have anti-inflammatory activity by binding to and destabilizing pro-inflammatory mRNAs such as Tnf mRNA, and represent a potential therapeutic target for inflammatio...
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Article
Open AccessDirect and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes
Vitamin A (VA) deficiency induces a type 1 cytokine response and exogenously provided retinoids can induce a type 2 cytokine response both in vitro and in vivo. The precise mechanism(s) involved in this phenotypi...
