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Article
Open AccessCell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity
The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role in mouse melanoma tumor growth. Loss of Bmal1 in YU...
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Article
Open AccessAuthor Correction: Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis
The original version of this Article contained an error in the spelling of the author Brett L. Ecker, which was incorrectly given as Brett Ecker. This has now been corrected in both the PDF and HTML versions o...
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Article
Open AccessLoss of Phd2 cooperates with BRAFV600E to drive melanomagenesis
Prolyl hydroxylase domain protein 2 (PHD2) is a well-known master oxygen sensor. However, the role of PHD2 in tumor initiation remains controversial. We find that during the transition of human nevi to melanom...
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Article
Open AccessThe growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
Although a high frequency of androgen receptor (AR) expression in human breast cancers has been described, exploiting this knowledge for therapy has been challenging. This is in part because androgens can eith...
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Article
Open AccessDirect and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes
Vitamin A (VA) deficiency induces a type 1 cytokine response and exogenously provided retinoids can induce a type 2 cytokine response both in vitro and in vivo. The precise mechanism(s) involved in this phenotypi...
