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Article
A readily retrievable pool of synaptic vesicles
Because clathrin-mediated endocytosis (CME) is relatively slow, it's been suggested that a readily retrievable pool of synaptic vesicle proteins might support fast CME. The authors use a recently developed pro...
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Chapter
Gravitational Force: Triggered Stress in Cells of the Immune System
Sensitivity of the human immune system to microgravity has been supposed since the first Apollo missions and was demonstrated during several space missions in the past. In vitro experiments demonstrated that c...
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Article
Open AccessRapid alterations of cell cycle control proteins in human T lymphocytes in microgravity
In our study we aimed to identify rapidly reacting gravity-responsive mechanisms in mammalian cells in order to understand if and how altered gravity is translated into a cellular response. In a combination of...
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Chapter
Cellular Effects of Altered Gravity on the Human Adaptive Immune System
Functional deterioration of immune cells has been recorded in real microgravity during spaceflights or parabolic flights and in ground-based facilities in order to simulate microgravity. Numerous in vitro stud...
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Article
Open AccessRapid adaptation to microgravity in mammalian macrophage cells
Despite the observed severe effects of microgravity on mammalian cells, many astronauts have completed long term stays in space without suffering from severe health problems. This raises questions about the ce...
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Article
Open AccessDynamic gene expression response to altered gravity in human T cells
We investigated the dynamics of immediate and initial gene expression response to different gravitational environments in human Jurkat T lymphocytic cells and compared expression profiles to identify potential...
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Article
Open AccessStability of gene expression in human T cells in different gravity environments is clustered in chromosomal region 11p15.4
In the last decades, a plethora of in vitro studies with living human cells contributed a vast amount of knowledge about cellular and molecular effects of microgravity. Previous studies focused mostly on the i...
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Article
Open AccessRapid coupling between gravitational forces and the transcriptome in human myelomonocytic U937 cells
The gravitational force has been constant throughout Earth’s evolutionary history. Since the cell nucleus is subjected to permanent forces induced by Earth’s gravity, we addressed the question, if gene express...
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Living Reference Work Entry In depth
Effects of Spaceflight on the Immune System
The immune system belongs to the most affected systems during spaceflight, and sensitivity of cells of the human immune system to reduced gravity has been confirmed in numerous studies in real and simulated mi...
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Chapter
Cellular and Molecular Responses to Gravitational Force-Triggered Stress in Cells of the Immune System
Sensitivity of the human immune system to microgravity has been supposed since the first Apollo missions and was demonstrated during several space missions in the past. In vitro experiments demonstrated that c...
-
Reference Work Entry In depth
Effects of Spaceflight on the Immune System
The immune system belongs to the most affected systems during spaceflight, and sensitivity of cells of the human immune system to reduced gravity has been confirmed in numerous studies in real and simulated mi...
-
Article
Open AccessExpression of hypoxia-inducible genes is suppressed in altered gravity due to impaired nuclear HIF1α accumulation
Extravehicular activities, the backbone of manned space exploration programs, set astronauts into mild hypoxia. Unfortunately, microgravity aggravates threatening symptoms of hypoxia such as vision impairment ...
