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Open AccessNanoemulsions and nanocapsules as carriers for the development of intranasal mRNA vaccines
The global emergency of coronavirus disease 2019 (COVID-19) has spurred extensive worldwide efforts to develop vaccines for protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our ...
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Open AccessDeep optoacoustic localization microangiography of ischemic stroke in mice
Super-resolution optoacoustic imaging of microvascular structures deep in mammalian tissues has so far been impeded by strong absorption from densely-packed red blood cells. Here we devised 5 µm biocompatible ...
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Open AccessAuthor Correction: A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer
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Open AccessA nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer
Despite therapeutic advancements, oral cavity squamous cell carcinoma (OCSCC) remains a difficult disease to treat. Systemic platinum-based chemotherapy often leads to dose-limiting toxicity (DLT), affecting q...
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Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation
Current pharmacological therapies for treating obesity are of limited efficacy. Genetic ablation or loss of function of AMP-activated protein kinase alpha 1 (AMPKα1) in steroidogenic factor 1 (SF1) neurons of ...
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Open AccessO-GlcNAcylated p53 in the liver modulates hepatic glucose production
p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes cellular metabolic stress, and we...
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Article
Delivery of transcription factors as modulators of cell differentiation
Fundamental studies performed during the last decades have shown that cell fate is much more plastic than previously considered, and technologies for its manipulation are a keystone for many new tissue regener...
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SUMOylation modulates the stability and function of PI3K-p110β
Class I PI3K are heterodimers composed of a p85 regulatory subunit and a p110 catalytic subunit involved in multiple cellular functions. Recently, the catalytic subunit p110β has emerged as a class I PI3K isof...
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Open AccessAuthor Correction: Identification and characterization of Cardiac Glycosides as senolytic compounds
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessIdentification and characterization of Cardiac Glycosides as senolytic compounds
Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Car...
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Open AccessPhosphorylable tyrosine residue 162 in the double-stranded RNA-dependent kinase PKR modulates its interaction with SUMO
Activated dsRNA-dependent serine/threonine kinase PKR phosphorylates the alpha subunit of eukaryotic initiation factor 2 (eIF2α), resulting in a shut-off of general translation, induction of apoptosis, and inh...
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Open AccessCorrection: Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress
Nature Communications 8: Article number:15111 (2017); Published: 8 May 2017; Updated: 16 June 2017 The affiliation details for Paula Iruzubieta and Javier Crespo are incorrect in this Article. The correct affi...
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Open AccessHepatic p63 regulates steatosis via IKKβ/ER stress
p53 family members control several metabolic and cellular functions. The p53 ortholog p63 modulates cellular adaptations to stress and has a major role in cell maintenance and proliferation. Here we show that ...
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Open AccessCell senescence is an antiviral defense mechanism
Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activator...
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Open AccessSelective interaction of PEGylated polyglutamic acid nanocapsules with cancer cells in a 3D model of a metastatic lymph node
Metastases are the most common reason of cancer death in patients with solid tumors. Lymph nodes, once invaded by tumor cells, act as reservoirs before cancer cells spread to distant organs. To address the lim...
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Transcriptional repression of Bmp2 by p21Waf1/Cip1 links quiescence to neural stem cell maintenance
The self renewal and long-term maintenance of neural stem cells (NSCs) is related to how quickly they pass through the cell cycle. Here the authors describe a new role for the cyclin-dependent kinase inhibitor...
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TGF-β1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth
Little is known about the TGF-β1 mechanism that promotes thyroid cell growth arrest. We assessed TGF-β1 effects on Fisher rat thyroid cell line (FRTL-5). This allowed us to study TGF-β1 action on thyroid cells...
