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Open AccessMethionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
Altered methionine metabolism is associated with weight gain in obesity. The methionine adenosyltransferase (MAT), catalyzing the first reaction of the methionine cycle, plays an important role regulating lipi...
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Article
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation
Current pharmacological therapies for treating obesity are of limited efficacy. Genetic ablation or loss of function of AMP-activated protein kinase alpha 1 (AMPKα1) in steroidogenic factor 1 (SF1) neurons of ...
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Article
Open AccessO-GlcNAcylated p53 in the liver modulates hepatic glucose production
p53 regulates several signaling pathways to maintain the metabolic homeostasis of cells and modulates the cellular response to stress. Deficiency or excess of nutrients causes cellular metabolic stress, and we...
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Article
Open AccessVav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
Skeletal muscle promotes metabolic balance by regulating glucose uptake and the stimulation of multiple interorgan crosstalk. We show here that the catalytic activity of Vav2, a Rho GTPase activator, modulates...
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Article
Hypothalamic dopamine signalling regulates brown fat thermogenesis
Dopamine signalling is a crucial part of the brain reward system and can affect feeding behaviour. Dopamine receptors are also expressed in the hypothalamus, which is known to control energy metabolism in peri...
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Open AccessPublisher Correction: Obestatin controls skeletal muscle fiber-type determination
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet
The identification of mediators in the pathogenesis of type 2 diabetes mellitus is essential for the full understanding of this disease. Protein kinases are especially important because of their potential as p...
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Open AccessCorrection: Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress
Nature Communications 8: Article number:15111 (2017); Published: 8 May 2017; Updated: 16 June 2017 The affiliation details for Paula Iruzubieta and Javier Crespo are incorrect in this Article. The correct affi...
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Article
Open AccessObestatin controls skeletal muscle fiber-type determination
Obestatin/GPR39 signaling stimulates skeletal muscle growth and repair by inducing both G-protein-dependent and -independent mechanisms linking the activated GPR39 receptor with distinct sets of accessory and ...
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Article
Open AccessHepatic p63 regulates steatosis via IKKβ/ER stress
p53 family members control several metabolic and cellular functions. The p53 ortholog p63 modulates cellular adaptations to stress and has a major role in cell maintenance and proliferation. Here we show that ...
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Article
Open AccessObesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice
Somatostatin (SST) and cortistatin (CORT) regulate numerous endocrine secretions and their absence [knockout (KO)-models] causes important endocrine-metabolic alterations, including pituitary dysregulations. W...
