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Open AccessAuthor Correction: dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe
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Open AccessdsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe
The E3 SUMO ligase PIAS2 is expressed at high levels in differentiated papillary thyroid carcinomas but at low levels in anaplastic thyroid carcinomas (ATC), an undifferentiated cancer with high mortality. We sho...
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Open AccessImproved guidance is needed to optimise diagnostics and treatment of patients with thyroid cancer in Europe
Although thyroid cancer (TC) is generally associated with a favourable prognosis, there are certain high-risk groups with a clear unmet therapeutic need. Unravelling the genomic landscape of TC has recently le...
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Open AccessCorrection: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas
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Open AccessData mining analyses for precision medicine in acromegaly: a proof of concept
Predicting which acromegaly patients could benefit from somatostatin receptor ligands (SRL) is a must for personalized medicine. Although many biomarkers linked to SRL response have been identified, there is n...
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Open AccessRET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomas
It is unclear how loss-of-function germline mutations in the widely-expressed co-chaperone AIP, result in young-onset growth hormone secreting pituitary tumours. The RET receptor, uniquely co-expressed in somatot...
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Open AccessCorrection to: A nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin
A correction to this paper has been published: https://doi.org/10.1007/s13346-021-00957-y
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Open AccessA nanoemulsion/micelles mixed nanosystem for the oral administration of hydrophobically modified insulin
The potential of nanoemulsions for the oral administration of peptides is still in its early stage. The aim of the present work was to rationally design, develop, and fully characterize a new nanoemulsion (NE)...
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Open AccessMKK6 controls T3-mediated browning of white adipose tissue
Increasing the thermogenic capacity of adipose tissue to enhance organismal energy expenditure is considered a promising therapeutic strategy to combat obesity. Here, we report that expression of the p38 MAPK ...
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Open AccessThe syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways
IGSF1 (Immunoglobulin Superfamily 1) gene defects cause central hypothyroidism and macroorchidism. However, the pathogenic mechanisms of the disease remain unclear. Based on a patient with a full deletion of IGSF...
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TGF-β-induced apoptosis in human thyrocytes is mediated by p27kip1 reduction and is overridden in neoplastic thyrocytes by NF-κB activation
Millions of people worldwide suffer goiter, a proliferative disease of the follicular cells of the thyroid that may become neoplastic. Thyroid neoplasms have low proliferative index, low apoptotic index and a ...
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TGF-β1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth
Little is known about the TGF-β1 mechanism that promotes thyroid cell growth arrest. We assessed TGF-β1 effects on Fisher rat thyroid cell line (FRTL-5). This allowed us to study TGF-β1 action on thyroid cells...
