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Article
Benefits of cardiac pacing in ICD recipients with hypertrophic cardiomyopathy
Implantable cardiac defibrillator (ICD) is the only definitive therapy for prevention of sudden cardiac death in hypertrophic cardiomyopathy (HCM). Conventional transvenous ICDs can provide cardiac pacing unli...
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Protocol
Markers of Developmentally Regulated Programmed Cell Death and Their Analysis in Cereal Seeds
Programmed cell death (PCD) is a key process for the development and differentiation of multicellular organisms, which is characterized by well-defined morphological and biochemical features. These include chr...
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Article
Animal models of arrhythmogenic right ventricular cardiomyopathy: what have we learned and where do we go? Insight for therapeutics
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare genetically-determined cardiac heart muscle disorder characterized by fibro-fatty replacement of the myocardium that results in heart failure an...
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Article
Open AccessZero-energy pinning from interactions in Majorana nanowires
Majorana zero modes at the boundaries of topological superconductors are charge-neutral, an equal superposition of electrons and holes. This ideal situation is, however, hard to achieve in physical implementat...
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Chapter
Nuclear Dismantling Events: Crucial Steps During the Execution of Plant Programmed Cell Death
Programmed cell death (PCD) is an important process in the life cycle of multicellular organisms, which has the relevant function of eliminating unneeded or damaged cells. In response to either internal or ext...
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Article
Open AccessGenetic study of the hepcidin gene (HAMP) promoter and functional analysis of the c.-582A > G variant
Hepcidin acts as the main regulator of iron homeostasis through regulation of intestinal absorption and macrophage release. Hepcidin deficiency causes iron overload whereas its overproduction is associated wit...
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Article
TGF-β-induced apoptosis in human thyrocytes is mediated by p27kip1 reduction and is overridden in neoplastic thyrocytes by NF-κB activation
Millions of people worldwide suffer goiter, a proliferative disease of the follicular cells of the thyroid that may become neoplastic. Thyroid neoplasms have low proliferative index, low apoptotic index and a ...
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Article
A germination-related gene encoding a serine carboxypeptidase is expressed during the differentiation of the vascular tissue in wheat grains and seedlings
Carboxypeptidases expressed in the aleurone layer participate in the mobilization of endosperm storage proteins during cereal grain germination. The genes encoding these proteins are also expressed in the scu...
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Article
Role of inhibitors of isoprenylation in proliferation, phenotype and apoptosis of human retinal pigment epithelium
Background: Isoprenoid biosynthesis is known to be essential for diverse cellular functions, including cell proliferation. The aim of this work was to study the effects caused by the add...
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Article
TGF-β1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth
Little is known about the TGF-β1 mechanism that promotes thyroid cell growth arrest. We assessed TGF-β1 effects on Fisher rat thyroid cell line (FRTL-5). This allowed us to study TGF-β1 action on thyroid cells...
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Article
Immunohistochemical location of prothymosin alpha in regenerating human hepatocytes and hepatocellular carcinomas
In the present paper we analysed the presence of prothymosin alpha (ProT) in human liver. In normal liver, ProT immunostaining was found in the nuclei of bile duct cells, but not in the hepatocytes. In contras...
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Article
Carbon source control on β-glucanases, chitobiase and chitinase from Trichoderma harzianum
The cell-wall degrading enzymes β-glucanase and chitinase have been suggested to be essential for the mycoparasitic action of Trichoderma species against plant fungal pathogens. For this reason, the production in...
