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Protocol
Measuring the Kinase Activity of GCKIII Proteins In Vitro
One of the CCM genes, CCM3/PDCD10, binds to the protein kinase family GCKIII, which comprises MST3/STK24, SOK1/STK25, and MST4/STK26. These proteins have been shown to have the same effect as CCM3, both in end...
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Article
The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet
The identification of mediators in the pathogenesis of type 2 diabetes mellitus is essential for the full understanding of this disease. Protein kinases are especially important because of their potential as p...
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Article
Open AccessCorrection: Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress
Nature Communications 8: Article number:15111 (2017); Published: 8 May 2017; Updated: 16 June 2017 The affiliation details for Paula Iruzubieta and Javier Crespo are incorrect in this Article. The correct affi...
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Article
Open AccessHepatic p63 regulates steatosis via IKKβ/ER stress
p53 family members control several metabolic and cellular functions. The p53 ortholog p63 modulates cellular adaptations to stress and has a major role in cell maintenance and proliferation. Here we show that ...
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Protocol
Binding of SV40 Large T Antigen to the Retinoblastoma Susceptibility Gene Product and Related Proteins
SV40 large T antigen (T-ag) is an oncoprotein that induces transformation of cells through the binding and inactivation of the p53 tumor suppressor protein and the retinoblastoma family of proteins. This chapter ...
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Article
TGF-β1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth
Little is known about the TGF-β1 mechanism that promotes thyroid cell growth arrest. We assessed TGF-β1 effects on Fisher rat thyroid cell line (FRTL-5). This allowed us to study TGF-β1 action on thyroid cells...
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Article
Erratum: Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein
Nature 386, 177-181 (1997). Due to an error in the reproduction process, the labelling in the right-hand panel of Fig. 5b of this letter was incorrect. The cell type involved is not Rb+/+ 3T3, but Rb–/– 3T3, a...
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Article
Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein
The Ras proto-oncogene is a central component of mitogenic signal-transduction pathways, and is essential for cells both to leave a quiescent state (G0) and to pass through the G1/S transition of the cell cycle1...
