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Activation of human B lymphocytes
The characteristics of human B lymphocyte triggering, differentiation, and regulation are described using the polyclonally induced anti-sheep red blood cell hemolytic plaque-forming cell assay system. Technica...
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Article
A new immunodeficiency disorder in humans involving NK cells
Immunodeficiency disorders have provided much information on the development and interaction of the various B and T lymphoid components in the immune system of man. As the lymphoid system becomes increasingly ...
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Article
Regulation of human B-cell activation, proliferation, and differentiation by soluble factors
This review describes a series of studies performed in our laboratory which have focused on the activation and subsequent proliferation and differentiation of human B lymphocytes. Utilizing polyclonal signals ...
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Chapter
Human B-Cell Growth and Differentiation Factors Secreted by T-Cell Hybridomas
Application of the technique of cell hybridization (Köhler and Milstein, 1975) to human and murine T lymphocytes has been an area of recent intense interest and investigation. T-cell hybridomas have been devel...
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Exogenous IL-2 Independent Antigen-Specific Human T Cells: Antigen-Specific Induction of Polyclonal B Cell Factors
The development of antigen-specific T lymphocyte lines and clones has greatly facilitated the investigation of the mechanisms by which T cells recognize foreign antigens and subsequently elaborate immuoregulat...
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The Human B Cell Cycle: Activation, Proliferation, and Differentiation
The full expression of a competent immune response, either cell mediated or humoral, requires the precise cooperation of a number of cell types which communicate either by cell-to-cell contact or by soluble im...
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Chapter
Vasculitis
Vasculitis refers to the inflammation of and resultant damage to blood vessels, leading to ischemia of distal tissues (Fauci et al., 1978a; Cupps and Fauci, 1981). It is this ischemia with changes in distal tissu...
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Book
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Current Studies Examining Regulation of the Human B Cell Cycle
The study of human B cell physiology involves the evaluation of a wide array of functions performed by B lymphocytes including antigen presentation (1), maintenance of memory for antigen (2), lymphokine secret...
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Chapter
The Activation, Proliferation, and Differentiation of Human B Lymphocytes
Efforts to evaluate normal human B cell physiology have resulted in the development of a model in which a resting B cell must progress through stages of activation, proliferation, and differentiation before be...
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Article
Host defense againstMycobacterium-avium complex
Mycobacterium-avium complex (MAC) is an intracellular pathogen and the most common cause of widely disseminated bacterial infection in patients with the acquired immunodeficiency syndrome (AIDS). MAC is infreque...
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Chapter
Alternative Cytokines in the Immunoregulation of the Human B Cell Cycle
A variety of soluble factors have been described which regulate the growth and differentiation of human B lymphocytes in vitro. Several of these factors were orginally recognized by their activity in assays of...
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Article
A phase I trial of recombinant human interferon-γ in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome (AIDS)
A Phase I study of recombinant interferon-gamma (rIFN-γ) was conducted to determine the toxicity and pharmacokinetics of this lymphokine in acquired immunodeficiency syndrome (AIDS) patients with Kaposi's sarc...
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Article
Immunology of aids: Approaches to understanding the immunopathogenesis of HIV infection
Infection with human immunodeficiency virus (HIV) causes an extensive array of immunologic abnormalities which ultimately lead to severe immunosuppression, opportunistic disease, and death. Many of the immunol...
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Article
Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease
THE human T-lymphotropic virus type I (HTLV-I), the first human retrovirus to be characterized, is associated with adult T-cell leukaemia and a chronic progressive disease of the central nervous system termed ...
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Chapter
Limited Prognostic Value of Changes in Antineutrophil Cytoplasmic Antibody Titers in Patients with Wegener’s Granulomatosis
One hundred and six patients with Wegener’s granulomatosis (WG) were studied for the presence of antineutrophil cytoplasmic antibodies (ANCA). In 53 patients serial ANCA determinations were obtained. C-ANCA po...
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Article
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
PRIMARY infection with the human immunodeficiency virus (HIV) is generally followed by a burst of viraemia with or without clinical symptoms1–3. This in turn is followed by a prolonged period of clinical latency....
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Article
Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV
A SIGNIFICANT proportion (up to 70%) of individuals experience an acute clinical syndrome of varying severity associated with primary infection with the human immunodeficiency virus (HIV)1–4. We report here studi...
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Article
Apoptosis in HIV infection
It is reported that DNA fragmentation (indicating apoptosis) is rarely observed in HIV-1 or SIV-producing infected cells, and HIV-1 or SIV RNA is rarely (0-1%) observed in apoptotic cells. What is the role of ...
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Article
Trapped but still dangerous
