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Article
Open AccessReliable Genotypic Tropism Tests for the Major HIV-1 Subtypes
Over the past decade antiretroviral drugs have dramatically improved the prognosis for HIV-1 infected individuals, yet achieving better access to vulnerable populations remains a challenge. The principal obsta...
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Article
Open AccessUpdate on Aplaviroc: An HIV Entry Inhibitor Targeting CCR5
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Article
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression
An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 net protein. This clone was adoptively transferred to determine whether sup...
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Article
Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV
A SIGNIFICANT proportion (up to 70%) of individuals experience an acute clinical syndrome of varying severity associated with primary infection with the human immunodeficiency virus (HIV)1–4. We report here studi...
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Article
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
PRIMARY infection with the human immunodeficiency virus (HIV) is generally followed by a burst of viraemia with or without clinical symptoms1–3. This in turn is followed by a prolonged period of clinical latency....
