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Open AccessNovel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial
Despite evidence associating inflammatory biomarkers with worse outcomes in hospitalized adults with COVID-19, trials of immunomodulatory therapies have met with mixed results, likely due in part to biological...
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Open AccessQuantitative PET imaging of the CD4 pool in nonhuman primates
Previous SPECT and PET semi-quantitative in vivo imaging studies in monkeys have demonstrated specific uptake of radiolabeled rhesus recombinant anti-CD4 monoclonal antibody fragment CD4R1-F(ab΄)2 in the spleen a...
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Article
Open AccessPlasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19
Studies quantifying SARS-CoV-2 have focused on upper respiratory tract or plasma viral RNA with inconsistent association with clinical outcomes. The association between plasma viral antigen levels and clinical...
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Open AccessCorrection to: Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries
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Article
Open AccessPartnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries
The Ebola virus disease (EVD) outbreak in 2014–2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preve...
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Open AccessBrain 18F-FDG PET of SIV-infected macaques after treatment interruption or initiation
Although rates of severe HIV-associated neurocognitive disorders have declined in the post-antiretroviral treatment (ART) era, subtle deficits persist, possibly exacerbated by treatment non-adherence. The actu...
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Article
Open AccessInterleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox
Interleukin (IL)-27, a member of the IL-12 cytokine family, plays an important and diverse role in the function of the immune system. We have previously demonstrated that IL-27 is an anti-viral cytokine which ...
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Article
Open AccessRapid Recall Ability of Memory T cells is Encoded in their Epigenome
Even though T-cell receptor (TCR) stimulation together with co-stimulation is sufficient for the activation of both naïve and memory T cells, the memory cells are capable of producing lineage specific cytokine...
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Open AccessEpigenetic regulation of gene expression and cellular differentiation
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Open AccessHIV-1 infected monozygotic twins: a tale of two outcomes
Replicate experiments are often difficult to find in evolutionary biology, as this field is inherently an historical science. However, viruses, bacteria and phages provide opportunities to study evolution in b...
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Article
Getting personal about treating HIV
Genetic variants have been identified that may predict the response to HIV treatment (pages 413–420).
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Open AccessDAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis
Due to the complex and distributed nature of biological research, our current biological knowledge is spread over many redundant annotation databases maintained by many independent groups. Analysts usually nee...
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Open AccessThe DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists
The DAVID Gene Functional Classification Tool http://david.abcc.ncifcrf.gov uses a novel agglomeration algorithm to condense a list of genes or associated bi...
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Reports on nevirapine threaten public health
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Identifying biological themes within lists of genes with EASE
EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE and other high-throughput genomic data. The biologica...
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Article
DAVID: Database for Annotation, Visualization, and Integrated Discovery
The distributed nature of biological knowledge poses a major challenge to the interpretation of genome-scale datasets, including those derived from microarray and proteomic studies. This report describes DAVID...
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Article
Identifying biological themes within lists of genes with EASE
EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE, and other high-throughput genomic data. The biologic...
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Article
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Functional annotation of differentially expressed genes is a necessary and critical step in the analysis of microarray data. The distributed nature of biological knowledge frequently requires researchers to na...
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Article
Bioterrorism: A clear and present danger
The anthrax attacks in the United States, juxtaposed against the September 11 terrorist attacks on New York and Washington, DC, have transformed a theoretical threat to stark reality. The biomedical research c...
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Immunologic Approaches to the Therapy of Patients with HIV Infection
The primary modality of therapy for patients with human immunodeficiency virus (HIV) infection is the use of combination antiretroviral chemotherapy to suppress HIV replication. As has been clearly established...
