Abstract
The development of antigen-specific T lymphocyte lines and clones has greatly facilitated the investigation of the mechanisms by which T cells recognize foreign antigens and subsequently elaborate immuoregulatory lymphokines. Human antigen-specific helper T cell lines and clones have now been developed by the method of cyclic restimulation with antigen1,2 which are completely independent of exogenous interleukin-2 (IL-2) for their growth. Following a narrowly restricted stimulation signal with the appropriate antigen in the context of histocompatible antigen-presenting cells (APC), these T cells can produce several polyclonal B cell factors which act on discrete subsets of B cells depending on their state of activation or receptiveness to these lymphokines.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Kishimoto, M. & Fathman, C. G. J. exp. Med. 152, 759–770 (1982).
Volkman, D. J., Matis, L. A. & Fauci, A. S. Cell. Immunol. (in the press).
Nutman, T. B., Ottesen, E. A., Fauci, A. S. & Volkman, D. J. J. Clin. Invest. 73, 1754–1762 (1984).
Sredni, B., Volkman, D., Schwartz, R. H. & Fauci, A. S. Proc. natl. Acad. Sci. U.S.A. 78, 1858–1862 (1981).
Muraguchi, A. & Fauci, A. S. J. Immunol. 129, 1104–1108 (1981).
Muraguchi, A., Kishimoto, T., et al. J. Immunol. 127, 412 (1981).
Nutman, T. B., Volkman, D. J., Hussain, R., Fauci, A. S. & Ottesen, E. A. J. Immunol, (in the press).
Lamb, J. R., Woody, J. N., Hartzman, R. J. & Eckels, D. D. J. Immunol. 129, 1465–1470 (1982)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 The Humana Press Inc.
About this chapter
Cite this chapter
Volkman, D.J., Nutman, T.B., Ottesen, E.A., Fauci, A.S. (1985). Exogenous IL-2 Independent Antigen-Specific Human T Cells: Antigen-Specific Induction of Polyclonal B Cell Factors. In: Feldmann, M., Lamb, J.R., Woody, J.N. (eds) Human T Cell Clones. Experimental Biology and Medicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4998-6_12
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4998-6_12
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9391-0
Online ISBN: 978-1-4612-4998-6
eBook Packages: Springer Book Archive