16 Result(s)

Article

A new immunodeficiency disorder in humans involving NK cells

Immunodeficiency disorders have provided much information on the development and interaction of the various B and T lymphoid components in the immune system of man. As the lymphoid system becomes increasingly ...

John C. Roder, Tina Haliotis, Margareta Klein, Stefan Korec, James R. Jett… in Nature (1980)

Article

Circulating CD8⁺ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease

THE human T-lymphotropic virus type I (HTLV-I), the first human retrovirus to be characterized, is associated with adult T-cell leukaemia and a chronic progressive disease of the central nervous system termed ...

Steven Jacobson, Hisatoshi Shida, Dale E. McFarlin, Anthony S. Fauci… in Nature (1990)

Article

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

PRIMARY infection with the human immunodeficiency virus (HIV) is generally followed by a burst of viraemia with or without clinical symptoms^1–3. This in turn is followed by a prolonged period of clinical latency....

Giuseppe Pantaleo, Cecilia Graziosi, James F. Demarest, Luca Butini… in Nature (1993)

Article

Major expansion of CD8⁺ T cells with a predominant Vβ usage during the primary immune response to HIV

A SIGNIFICANT proportion (up to 70%) of individuals experience an acute clinical syndrome of varying severity associated with primary infection with the human immunodeficiency virus (HIV)^1–4. We report here studi...

Giuseppe Pantaleo, James F. Demarest, Hugo Soudeyns, Cecilia Graziosi… in Nature (1994)

Article

Trapped but still dangerous

Lewis K. Schrager, Anthony S. Fauci in Nature (1995)

Article

Host factors and the pathogenesis of HIV-induced disease

The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the ce...

Anthony S. Fauci in Nature (1996)

Article

Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) enter target cells by forming a complex between the viral envelope protein and two cell-surface membrane receptors: CD4 and a 7-span t...

Drew Weissman, Ronald L. Rabin, James Arthos, Andrea Rubbert, Mark Dybul… in Nature (1997)

Article

Re-emergence of HIV after stop** therapy

A dormant reservoir of human immuno-deficiency virus (HIV) is established early on during primary infection¹ which consists of latently infected, resting CD4⁺ T cells carrying replication-competent HIV. This pool...

Tae-Wook Chun, Richard T. Davey Jr, Delphine Engel, H. Clifford Lane… in Nature (1999)

Article

Early antibody therapy can induce long-lasting immunity to SHIV

Early administration of broadly neutralizing antibodies in a macaque SHIV infection model is associated with very low levels of persistent viraemia, which leads to the establishment of T-cell immunity and resu...

Yoshiaki Nishimura, Rajeev Gautam, Tae-Wook Chun, Reza Sadjadpour… in Nature (2017)