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Open AccessGenetic sequencing of a 1944 Rocky Mountain spotted fever vaccine
Rocky Mountain spotted fever (RMSF) is a rapidly progressive and often fatal tick-borne disease caused by Rickettsia rickettsii. Its discovery and characterization by Howard Ricketts has been hailed as a remarkab...
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Donald Millis McLean (1926–2022): a humble and devoted scientist
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The “Golden Age” of Arbovirology, 1950–1969
Although arbovirology’s origin might be considered to have been no later than 1900, when the Walter Reed Commission established the mechanism of spread of yellow fever, it was not until the mid-twentieth centu...
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Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model
The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target for universal influenza vaccines1–5. Although the HA stalk region is relatively well conserved, the evo...
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Dengue: The Continual Re-Emergence of a Centuries-Old Disease
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Engineering H5N1 avian influenza viruses to study human adaptation
Engineering influenza viruses to study human adaptation is a controversial area of research, with opinions diverging over the wisdom of publishing the full results of such studies.
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Remembering Daumier’s Blue Period
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The challenge of emerging and re-emerging infectious diseases
Infectious diseases have for centuries ranked with wars and famine as major challenges to human progress and survival. They remain among the leading causes of death and disability worldwide. Against a constant...
