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  1. Article

    Combination anti-HIV antibodies provide sustained virological suppression

    Antiretroviral therapy is highly effective in suppressing human immunodeficiency virus (HIV)1. However, eradication of the virus in individuals with HIV has not been possible to date2. Given that HIV suppression ...

    Michael C. Sneller, Jana Blazkova, J. Shawn Justement, Victoria Shi… in Nature (2022)

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    Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy

    Certain infected individuals suppress human immunodeficiency virus (HIV) in the absence of anti-retroviral therapy (ART). Elucidating the underlying mechanism(s) is of high interest. Here we present two contra...

    Jana Blazkova, Feng Gao, Manukumar Honnayakanahalli Marichannegowda… in Nature Medicine (2021)

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    IgG3 regulates tissue-like memory B cells in HIV-infected individuals

    Immunoglobulin G3 (IgG3) has an uncertain role in the response to infection with and vaccination against human immunodeficiency virus (HIV). Here we describe a regulatory role for IgG3 in dampening the immune ...

    Lela Kardava, Haewon Sohn, Christine Youn, James W. Austin, Wei Wang… in Nature Immunology (2018)

  4. Article

    Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes

    The antigenic polymorphism of HIV-1 is a major obstacle in develo** an effective vaccine. Accordingly, we screened random peptide libraries (RPLs) displayed on phage with antibodies from HIV-infected individ...

    Xueni Chen, Giuseppe Scala, Ileana Quinto, Weimin Liu, Tae-Wook Chun… in Nature Medicine (2001)

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    Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy

    We examined the pathogenic significance of the latent viral reservoir in the resting CD4+ T cell compartment of HIV-1-infected individuals as well as its involvement in the rebound of plasma viremia after discont...

    Tae-Wook Chun, Richard T. Davey Jr., Mario Ostrowski, J. Shawn Justement… in Nature Medicine (2000)