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Article
Open AccessEarly combination therapy of COVID-19 in high-risk patients
Prolonged shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed in immunocompromised hosts. Early monotherapy with direct-acting antivirals or monoclonal antibodies, as rec...
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Article
Open AccessIntramedullary leukocytoclastic vasculitis and neutrophil extracellular trap (NET) formation in POEMS syndrome
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Article
Open AccessCardiovascular Magnetic Resonance Assessment of Immunotherapy Cardiotoxicity
To review the current and future role of cardiovascular magnetic resonance (CMR) assessment of immunotherapy cardiotoxicity.
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Article
Open AccessTotal marrow irradiation versus total body irradiation using intensity-modulated helical tomotherapy
Total body irradiation (TBI) is often a component of the conditioning regimen prior to hematopoietic stem cell transplantation in patients with hematological malignancies. However, total marrow irradiation (TM...
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Article
Open AccessWhole body irradiation with intensity-modulated helical tomotherapy prior to haematopoietic stem cell transplantation: analysis of organs at risk by dose and its effect on blood kinetics
Intensity-modulated helical tomotherapy (HT) is a promising technique in preparation for bone marrow transplantation. Nevertheless, radiation-sensitive organs can be substantially compromised due to suboptimal...
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Article
Open AccessTwo cases of EBV infection preceding lymphoma
Infection of lymphocytes with the Epstein-Barr virus (EBV) is a well-documented risk factor for develo** lymphoma. The incidence of EBV positivity in lymphoma depends on the subtype and can range from 10% in...
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Article
Open AccessSARS-CoV-2 PrEP complicates antibody testing after vaccination: a call for awareness
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Article
Open AccessBlastic plasmacytoid dendritic-cell neoplasia: a challenging case report
Blastic plasmacytoid dendritic-cell neoplasm (BPDCN) is an extremely rare disease that originates from dendritic cells and is associated with a poor overall survival (OS). Diagnostic and therapeutic standards ...
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Article
Open AccessVemurafenib as bridging therapy of hairy cell leukemia in a Jehovah’s Witness patient
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Article
Open AccessThe PI3Kδ inhibitor idelalisib impairs the function of human dendritic cells
The PI3Kδ-inhibitor Idelalisib is approved for the treatment of Non-Hodgkin lymphoma. However, its use has been decreased within the last years due to deleterious infections such as cytomegalovirus and pneumoc...
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Article
Open AccessElotuzumab spares dendritic cell integrity and functionality
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Article
Open AccessClinical and immunological effects of mRNA vaccines in malignant diseases
In vitro-transcribed messenger RNA-based therapeutics represent a relatively novel and highly efficient class of drugs. Several recently published studies emphasize the potential efficacy of mRNA vaccines in trea...
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Article
Open AccessBG-flow, a new flow cytometry tool for G-quadruplex quantification in fixed cells
Nucleic acids can fold into non-canonical secondary structures named G-quadruplexes (G4s), which consist of guanine-rich sequences stacked into guanine tetrads stabilized by Hoogsteen hydrogen bonding, π-π int...
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Article
Open AccessG-quadruplexes: a promising target for cancer therapy
DNA and RNA can fold into a variety of alternative conformations. In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. This stru...
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Article
Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal
Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs), populate inflamed or cancerous tissue and block immune cell effector functions. The lack of mechanistic insight into MDSC supp...
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Article
The role of checkpoint blockade after allogeneic stem cell transplantation in diseases other than Hodgkin’s Lymphoma
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment option for many malignant high-risk hematological diseases. The Graft-vs.-Tumor (GvT) effect is the major hallmark ...
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Article
Open AccessDexamethasone induced inhibition of Dectin-1 activation of antigen presenting cells is mediated via STAT-3 and NF-κB signaling pathways
Treatment of patients with glucocorticoids can result in an increased risk of infection with pathogens such as fungi. Dectin-1 is a member of the C-type lectin receptor superfamily and was shown to be one of t...
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Article
The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib
Increased numbers of immunosuppressive myeloid derived suppressor cells (MDSCs) correlate with a poor prognosis in cancer patients. Tyrosine kinase inhibitors (TKIs) are used as standard therapy for the treat...
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Article
Open AccessAnalysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma
Multiple myeloma (MM) is a clonal B cell malignancy characterized by proliferation of malignant plasma cells in the bone marrow. Despite high-dose melphalan therapy with autologous stem cell transplantation (A...
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Living Reference Work Entry In depth
Nierenzellkarzinom
Das Nierenzellkarzinom ist ein vom Nierenparenchym ausgehender maligner Tumor, der ca. 2–3 % aller bösartigen Erkrankungen des Erwachsenen ausmacht. Es ist im Frühstadium symptomarm bzw. symptomlos. Aufgrund d...
