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Article
Imatinib mesylate and nilotinib affect MHC-class I presentation by modulating the proteasomal processing of antigenic peptides
Imatinib (IM) has been described to modulate the function of dendritic cells and T lymphocytes and to affect the expression of antigen in CML cells. In our study, we investigated the effect of the tyrosine kin...
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Article
Tumorvakzinierung beim metastasierten Nierenzellkarzinom
Das Nierenzellkarzinom (NCC) zählt zu den immunogenen Tumoren, die kaum auf eine Strahlen- oder Chemotherapie ansprechen, so dass weitere, neue Therapieoptionen dringend notwendig sind. Zur Behandlung des NCC ...
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Article
Generation of antigen-specific CTL responses using RGS1 mRNA transfected dendritic cells
Advances in tumor immunology and Identification of tumor-associated antigens (TAAs) provide a basis for the development of novel immunotherapies to treat malignant diseases. In order to identify novel TAAs, we...
