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Article
Open AccessIntramedullary leukocytoclastic vasculitis and neutrophil extracellular trap (NET) formation in POEMS syndrome
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Article
Open AccessHemophagocytic lymphohistiocytosis—how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature
Infection-associated secondary hemophagocytic lymphohistiocytosis (sHLH) is a potentially life-threatening hyperinflammatory condition caused by various infectious diseases. Malaria has rarely been described a...
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Article
Open AccessA qPCR to quantify Wolbachia from few Onchocerca volvulus microfilariae as a surrogate for adult worm histology in clinical trials of antiwolbachial drugs
The filarial nematode Onchocerca volvulus causes onchocerciasis (river blindness), a neglected tropical disease affecting 21 million people, mostly in Sub-Saharan Africa. Targeting the endosymbiont Wolbachia with...
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Lymphatic and Tissue Filariasis
The range and burden of neglected tropical diseases, many of which are helminth-derived, remains enormous. Infections are rampant in poor districts, and although efforts have been implemented over the years, t...
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Article
Open AccessHuman filariasis—contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model
Filariae are vector-borne parasitic nematodes that are endemic worldwide, in tropical and subtropical regions. Important human filariae spp. include Onchocerca volvulus, Wuchereria bancrofti and Brugia spp., and
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Article
Open AccessImplications of asymptomatic infection for the natural history of selected parasitic tropical diseases
Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are not dealt ...
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Article
Open AccessSusceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils
Mice are susceptible to infections with the rodent filarial nematode Litomosoides sigmodontis and develop immune responses that resemble those of human filarial infections. Thus, the L. sigmodontis model is used ...
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Article
Open AccessNOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) recognizes muramyl dipeptide (MDP) of bacterial cell walls, triggering NFκB-induced pro-inflammation. As most human pathogenic filariae con...
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Article
Open AccessDevelopment of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses
One of the most advantageous research aspects of the murine model of filariasis, Litomosoides sigmodontis, is the availability of mouse strains with varying susceptibility to the nematode infection. In C57BL/6 mi...
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Chapter
Lymphatic and Tissue Filariasis
The range and burden of neglected tropical diseases, many of which are helminth-derived, remains enormous. Infections are rampant in poor districts and although efforts have been implemented over the years, th...