9 Result(s)
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Tobias A. W. Holderried
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Article
Open AccessECP versus ruxolitinib in steroid-refractory chronic GVHD – a retrospective study by the EBMT transplant complications working party
Ruxolitinib has become the new standard of care for steroid-refractory and steroid-dependent chronic GVHD (SR-cGVHD). Our aim was to collect comparative data between ruxolitinib and extracorporeal photophoresi...
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Open AccessCardiovascular Magnetic Resonance Assessment of Immunotherapy Cardiotoxicity
To review the current and future role of cardiovascular magnetic resonance (CMR) assessment of immunotherapy cardiotoxicity.
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Article
Open AccessHospital sanitary facilities on wards with high antibiotic exposure play an important role in maintaining a reservoir of resistant pathogens, even over many years
Hospitals with their high antimicrobial selection pressure represent the presumably most important reservoir of multidrug-resistant human pathogens. Antibiotics administered in the course of treatment are excr...
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Open AccessReal-world experience of CPX-351 as first-line treatment for patients with acute myeloid leukemia
To investigate the efficacy and toxicities of CPX-351 outside a clinical trial, we analyzed 188 patients (median age 65 years, range 26–80) treated for therapy-related acute myeloid leukemia (t-AML, 29%) or AM...
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Open AccessPrognostic and predictive value of PD-L2 DNA methylation and mRNA expression in melanoma
PD-L1 (programmed cell death 1 ligand 1) expression in melanoma has been associated with a better response to anti-PD-1 (programmed cell death 1) therapy. However, patients with PD-L1-negative melanomas can re...
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Open AccessMolecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanoma
The T cell immunoglobulin and mucin-domain containing-3 receptor TIM-3 (also known as hepatitis A virus cellular receptor 2, encoded by HAVCR2) and its ligand galectin 9 (LGALS9) are promising targets for immune ...
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The role of checkpoint blockade after allogeneic stem cell transplantation in diseases other than Hodgkin’s Lymphoma
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment option for many malignant high-risk hematological diseases. The Graft-vs.-Tumor (GvT) effect is the major hallmark ...
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Article
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Damaged erythrocytes accumulate in various pathological conditions, such as hemolytic anemia, anemia of inflammation, and sickle cell disease. In mice challenged with damaged erythorcytes, a monocyte subset mi...
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Tumorvakzinierung beim metastasierten Nierenzellkarzinom
Das Nierenzellkarzinom (NCC) zählt zu den immunogenen Tumoren, die kaum auf eine Strahlen- oder Chemotherapie ansprechen, so dass weitere, neue Therapieoptionen dringend notwendig sind. Zur Behandlung des NCC ...
