-
Article
Open AccessUV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence
Senescence has two roles in oncology: it is known as a potent tumor-suppressive mechanism, which also supports tissue regeneration and repair, it is also known to contribute to reduced patient resilience, whic...
-
Article
Open AccessClinical and immunological effects of mRNA vaccines in malignant diseases
In vitro-transcribed messenger RNA-based therapeutics represent a relatively novel and highly efficient class of drugs. Several recently published studies emphasize the potential efficacy of mRNA vaccines in trea...
-
Article
Open AccessG-quadruplexes: a promising target for cancer therapy
DNA and RNA can fold into a variety of alternative conformations. In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. This stru...
-
Article
Open AccessZuo1 supports G4 structure formation and directs repair toward nucleotide excision repair
Nucleic acids can fold into G-quadruplex (G4) structures that can fine-tune biological processes. Proteins are required to recognize G4 structures and coordinate their function. Here we identify Zuo1 as a nove...
-
Article
Open AccessAbstracts of the 52nd Workshop for Pediatric Research
-
Article
Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I
The innate immune system relies on a series of specific receptors that recognize RNAs that might come from viruses. The structure of the C terminal domain of one such receptor, RIG-I, in complex with 5'ppp-dsR...
-
Article
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
The slicer activity of the RNA-induced silencing complex resides within its Argonaute (Ago) component, in which the PIWI domain provides the catalytic residues governing guide-strand mediated site-specific cle...
-
Article
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
Here we report on a 3.0 Å crystal structure of a ternary complex of wild-type Thermus thermophilus argonaute bound to a 5′-phosphorylated 21-nucleotide guide DNA and a 20-nucleotide target RNA containing cleavage...
-
Article
Structure of the guide-strand-containing argonaute silencing complex
The slicer activity of the RNA-induced silencing complex is associated with argonaute, the RNase H-like PIWI domain of which catalyses guide-strand-mediated sequence-specific cleavage of target messenger RNA. ...
-
Article
Cell cycle-dependent regulation of telomere tethering in the nucleus
It is well established that telomeres are tethered in the eukaryotic nucleus, but a detailed analysis of the regulation of telomere attachment throughout the cell cycle is still lacking. We show here that the ...
-
Article
Telomerase recruitment by the telomere end binding protein-β facilitates G-quadruplex DNA unfolding in ciliates
The telomeric G-overhangs of the ciliate Stylonychia lemnae fold into a G-quadruplex DNA structure in vivo. Telomeric G-quadruplex formation requires the presence of two telomere end binding proteins, TEBPα and T...
