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Article
Open AccessAbaloparatide-SC improves trabecular microarchitecture as assessed by trabecular bone score (TBS): a 24-week randomized clinical trial
In a phase 2 trial of 222 postmenopausal women with osteoporosis aged 55 to 85 years randomized to one of three different doses of abaloparatide-SC, subcutaneous teriparatide, or placebo for 24 weeks, abalopar...
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Article
“Orthogonal polarization spectral imaging”Eine neue klinische Methode für das Monitoring der Mikrozirkulation
Mit “orthogonal polarization spectral imaging” (OPS-Imaging) steht ein neues nichtinvasives Untersuchungsverfahren zur Verfügung, das mikrovaskuläre Veränderungen am Menschen für verschiedene Organe direkt sic...
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Article
Open AccessOrthogonal polarisation spectral imaging as a new tool for the assessment of antivascular tumour treatment in vivo: a validation study
Tumour angiogenesis plays a key role in tumour growth, formation of metastasis, detection and treatment of malignant tumours. Recent investigations provided increasing evidence that quantitative analysis of tu...
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Chapter and Conference Paper
Quantitative Analyse der Mikrozirkulation von Wunden mit OPS imaging
Introduction: Orthogonal polarization spectral (OPS) imaging, implemented into the CYTOSCAN A/R, is a new, recently introduced technique to produce high contrast images of the microcirculation wi...
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Chapter and Conference Paper
The Study of the Microcirculation using Orthogonal Polarization Spectral Imaging
The microcirculation is an extremely important part of the body where blood interacts with tissue to create an environment necessary for cell survival [1]. As such, an understanding of its function under both ...
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Chapter and Conference Paper
Validierung des „OPS imaging“ Verfahrens an der Rattenleber
Hintergrund: Störungen der hepatischen Mikrozirkulation sind wesentlich an der Pathophysiologie der postischämischen Organdysfunktion nach Leberchirurgie sowie Trans-plantation beteiligt. Die qua...
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Article
Implementation of the Microdialysis Method in the Hamster Dorsal Skinfold Chamber
The aim of this study was to implement the microdialysis method, a well-established technique for measuring the local concentration of neurotransmitters and metabolites in the brain, in the dorsal skinfold cha...
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Chapter and Conference Paper
Langzeitkonservierung mit UW versus EC verbessert die Revaskularisierung des transplantierten Knochens
Zur Überbrückung langstreckiger Röhrenknochendefekte und zur Wiederherstellung der Gelenkfunktion nach Trauma wurde durch die allogene Transplantation vaskularisierter Knochen und Gelenke eine neue Behandlungs...
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Article
Solitary Hepatic Infantile Myofibromatosis in a Female Adolescent
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Chapter and Conference Paper
Oxaceprol reduziert die Leukozyten-Adhärenz und -Extravasation und erhält die Perfusion des Gewebes nach Ischämie/Reperfusion (I/R) aufrecht
Akkumulation von Leukozyten, Beeinträchtigung der Perfusion sowie Steigerung der Permeabilität kennzeichnen den mikrovaskulären Ischämie/Reperfusions (I/R)-Schaden. Das Antiphlogistikum Oxaceprol ist zugelasse...
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Article
Pyoderma gangrenosum with hepatopancreatic manifestations in a patient with rheumatoid arthritis
Pyoderma gangrenosum is a dermatological disease of unknown origin. We report the case of a 47-year-old woman with cutaneous lesions of pyoderma gangrenosum associated with hepaticopancreatic involvement. We f...
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Article
Consensus statement: Octreotide dose titration in secretory diarrhea
Octreotide is an effective therapeutic option in controlling secretory diarrhea of varied etiology. However, marked patient-to-patient differences in the antidiarrheal effects necessitate titration of octreoti...
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Article
A prospective multicenter octreotide dose response study in the treatment of acromegaly
The somatostatin analog octreotide has proven to be an effective form of treatment for various hypersecretory states including acromegaly. This report describes the effects of escalating doses of octreotide on...
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Article
Effects of octreotide on biliary lipid composition and occurrence of cholesterol crystals in patients with acromegaly
Treatment with the somatostatin analog octreotide is associated with increased gallstone formation. The mechanism of formation of these stones is unclear. The purpose of this study was to examine the effect of...
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Article
Clinical use of the long acting somatostatin analogue octreotide in pediatrics
Preliminary data of the use of the long-acting somatostatin analog octreotide (Sandostatin) in pediatrics are reported. In nesidioblastosis and other hyperinsulinemic conditions, timely treatment with octreoti...
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Chapter and Conference Paper
Receptors and Their Modulation
The potential for hormonal intervention in cancer was identified as early as 1895, even before the concept of hormones was established. Indeed, we know that the first hormone was discovered only in 1902 (secre...
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Article
Gallstones in acromegalic patients undergoing different treatment regimens
The frequency of gallstones during longterm treatment with the somatostatin analogue octreotide reported in different studies varies from 0% to 50%, the reason for this variation being unknown. Therefore, we e...
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Article
Reduction in sella turcica volume
Ten patients with acromegaly were treated with the long-acting somatostatin analogue, Sandostatin (SMS 201-995, octreotide) for more than one year. Computerized tomography was performed before and on 4 differe...
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Chapter and Conference Paper
Heart Size Reduction in Acromegalic Patientes Treated with the Long-Acting Somatostatin-Analogue SMS 201–995 (Somatostatin®)
Cardiomegaly by hypertrophy of the heart in acromegalic patients — prevalence 85% in our patients with acromegaly [1] — is often complicated by complex arrhythmias and gradual cardiac-insufficiency [1, 3, 8]. ...
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Chapter and Conference Paper
Effects of Long-Term Administration of Sandostatin® (SMS 201–995) at Increasing Doses in 40 Acromegalic Patients. Results from the French Sandostatin Acromegaly Study Group
Several studies demonstrate the efficacy of short- and long-term Sandostatin® treatment in acromegaly administered subcutaneously at doses ranging from 150 to 300 µg up to 600 µg per day [1, 3, 5, 7–10]. A rhythm...