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Article
Familial pituitary adenomas with a heterogeneous functional pattern: Clinical and genetic features
Familial pituitary adenoma is a rare syndrome which may present either as isolated lesions, or in association with other endocrine tumors, for example in the frame of multiple endocrine neoplasia (MEN-1) or Ca...
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Article
Clinical and histological correlations in prolactinomas, with special reference to bromocriptine resistance
Background. Prolactinomas usually exhibit a benign course and can be safely and effectively managed by dopamine agonists (DA). However, some are locally invasive and may show resistance to DA therapy, and the man...
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Article
Responses to gonadotropin releasing hormone agonist and antagonist administration in patients with gonadotroph cell adenomas
As they are clinically silent, gonadotroph cell pituitary adenomas are usually diagnosed only when pituitary enlargement causes visual impairment or hypopituitarism. In postmenopausal women presenting with pit...
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Chapter and Conference Paper
Sandostatin® in Digestive Endocrine Tumors
Some years ago, several authors reported that the tetradecapeptide somatostatin could be of value for the temporary control of inappropriate secretions from endocrine tumors of the digestive tract [2, 3, 5]. H...
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Chapter and Conference Paper
Effects of Long-Term Administration of Sandostatin® (SMS 201–995) at Increasing Doses in 40 Acromegalic Patients. Results from the French Sandostatin Acromegaly Study Group
Several studies demonstrate the efficacy of short- and long-term Sandostatin® treatment in acromegaly administered subcutaneously at doses ranging from 150 to 300 µg up to 600 µg per day [1, 3, 5, 7–10]. A rhythm...
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Article
Pharmacokinetics of human growth hormone releasing factor (hGRF-44 NH2) in normal men after intravenous administration of a large range of doses
Three ranges of doses of growth hormone releasing factor (2.5–80 µg, 80–320 µg and 75–600 µg) were intravenously administered to healthy young volunteers in three double blind studies.
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Article
CUSHING'S SYNDROME BY ECTOPIC ACTH SECRETION: EFFECT OF MIFEPRISTONE
Mifepristone (RU 486 - Roussel-Udlaf), an antiglucorticoid receptor with no agonist activity, has been proposed as treatment of hyper-cortisolism in adults. A 27 month old girl presented a Cushing's syndrome, ...
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Article
Synthetic human growth hormone releasing factor (h-GRF-I-44-NH2) dose response effect on growth hormone and prolactin secretion in healthy adult men
The dose-effect relationship of an i.v. bolus of synthetic h-GRF-44 on growth-hormone and prolactin secretion has been studied. Seven healthy adult volunteers received in a random order h-GRF-44 2.5, 5, 10, 20...